PPP1CB

Gene Symbol	PPP1CB
Entrez Gene	5500
Alt Symbol	HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD
Species	Human
Gene Type	protein-coding
Description	protein phosphatase 1, catalytic subunit, beta isozyme
Other Description	epididymis secretory sperm binding protein Li 80p|protein phosphatase 1, catalytic subunit, beta isoform|protein phosphatase 1, catalytic subunit, delta isoform|protein phosphatase 1-beta|protein phosphatase 1-delta|serine/threonine protein phosphatase PP1-beta catalytic subunit|serine/threonine-protein phosphatase PP1-beta catalytic subunit
Swissprots	B2R5V4 P37140 Q6FG45 Q5U087 P62140 D6W565
Accessions	AAA85093 AAY24124 EAX00527 EAX00528 EAX00529 EAX00530 P62140 AF092905 AAF01137 AI147919 AK295957 BAG58737 AK303682 BAG64675 AK312329 BAG35251 AK316532 BAH14903 AM392772 CAL37650 BC002697 AAH02697 BC012045 AAH12045 BE047402 BI551898 BM835970 BQ933435 BT019744 AAV38549 BU740022 BX477003 BX647295 BX647970 CB111140 CD656807 CD722576 CR542263 CAG47059 CR542285 CAG47080 EU668339 ACF94492 X80910 CAA56870 NM_002709 NP_002700 NM_206876 NP_996759 NM_206877
Function	Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T- cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). {ECO:
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus {ECO:0000269|PubMed:11739654}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus, nucleolus {ECO:0000269|PubMed:11739654}. Note=Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles.
Top Pathways	Amphetamine addiction, cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Protein Phosphatase 1 beta full length protein - ab128551 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human Protein Phosphatase 1 beta protein fragment - ab126018 from Abcam Category Protein Source E. coli Species Human

PPP1CB Antibody Blocking Peptide - LS-E2776 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1CB Antibody Blocking Peptide - LS-E9577 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1CB Antibody Blocking Peptide - LS-E23957 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PPP1CB Antibody Blocking Peptide - LS-E23958 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Protein Phosphatase 1 beta Protein - H00005500-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Protein Phosphatase 1 beta Peptide - P3266 from Novus Biologicals Category Peptide Species Human

PPP1CB-Antibody-C-term-Blocking-peptide - BP13874b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Protein-Phosphatase-1-beta-PPP1CB-Antibody-C-term-Blocking-peptide - BP8433b from Abgent, a WuXi AppTec company Category Protein Prices $80.00 Sizes 100 µg

PPP1CB - H00005500-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PPP1CB - H00005500-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PPP1CB fusion protein - ag0183 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human PPP1CB, GST-tagged - PPP1CB-1515H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human Serine/threonine-protein phosphatase PP1-beta catalytic subuni - CSB-YP018504HU CSB-EP018504HU CSB-BP018504HU CSB-MP018504HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PPP1CB (transcript variant 3) - TP301142 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Protein Phosphatase 1 beta Recombinant Protein Antigen - NBP2-49446PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

PPP1CB-Antibody-N-term-Blocking-Peptide - BP8473a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PPP1CB Peptide, Human - M34GP12227H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human Serine/threonine-protein phosphatase PP1-beta catalytic subunit(PPP1CB) - AP74141 from Signalway Antibody Category Protein Prices $105.00, $260.00, $454.00, $735.00, $1,240.00, $1,980.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Human

Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB), Recombinant Protein - MBS965220 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,710.00, $1,710.00, $2,170.00, $2,170.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Serine/threonine-protein phosphatase PP1-beta catalytic subunit (PPP1CB), Recombinant Protein - MBS9423721 from MyBioSource Category Protein Prices $165.00, $280.00, $435.00, $665.00, $1,080.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg Source E Coli Species Human

PPP1CB Recombinant Protein (Human) (OPCA04580) - OPCA04580 from Aviva Systems Biology Category Protein Species Human

Human PPP1CB protein - orb383387 from Biorbyt Category Protein Species Human

Recombinant Human PPP1CB Protein (2-327 aa), His-tagged - PPP1CB-2170H from Creative Biomart Category Protein Source E. coli Species Human

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