Gene Symbol |
ZP2
|
Entrez Gene |
7783
|
Alt Symbol |
ZPA, Zp-2
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
zona pellucida glycoprotein 2 (sperm receptor)
|
Other Description |
zona pellucida glycoprotein ZP2|zona pellucida protein A|zona pellucida sperm-binding protein 2
|
Swissprots |
Q4VAN9 Q4VAP1 Q4VAP0 B2R7J2 Q05996
|
Accessions |
AAB67599 EAW66859 EAW66860 Q05996 AK293805 BAG57212 AK308820 AK310454 AK313003 BAG35839 BC096304 AAH96304 BC096305 AAH96305 BC096306 AAH96306 BC096307 AAH96307 M90366 AAA61335 XM_011545942 XP_011544244 NM_001290104 NP_001277033 NM_003460 NP_003451
|
Function |
The mammalian zona pellucida, which mediates species- specific sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy, is composed of three to four glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP2 may act as a secondary sperm receptor.
|
Subcellular Location |
Processed zona pellucida sperm-binding protein 2: Secreted, extracellular space, extracellular matrix. Note=The glycoproteinaceous translucent extracellular matrix that surrounds the mammalian oocyte is called zona pellucida.
|
Tissue Specificity |
Oocytes.
|