SHANK3

Gene Symbol	SHANK3
Entrez Gene	85358
Alt Symbol	DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
Species	Human
Gene Type	protein-coding
Description	SH3 and multiple ankyrin repeat domains 3
Other Description	SH3 and multiple ankyrin repeat domains protein 3|proline rich synapse associated protein 2|shank postsynaptic density protein
Swissprots	Q8TET3 D7UT47 Q9BYB0
Accessions	ABA00478 ADY38945 ADY38946 ADY38947 AFO66271 Q9BYB0 AB051437 BAB33320 AB569469 BAJ09793 AK074038 BAB84864 BC018856 BC045765 BC062987 AAH62987 NM_033517 NP_277052 NM_001080420
Function	Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor- mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24132240}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269|PubMed:24132240}. Cell projection, dendritic spine {ECO:0000250}. Note=In neuronal cells, extends into the region subjacent to the postsynaptic density (PSD). {ECO:0000250}.
Tissue Specificity	Expressed in the cerebral cortex and the cerebellum.
Top Pathways	Glutamatergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Shank 3 (C-4) - sc-377088 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Shank 3 (H-160) - sc-30193 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Shank 3 (E-1) - sc-377470 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Shank 3 (N-16) - sc-23547 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SHANK3 antibody - ab140030 from Abcam Host Rabbit Clonality Polyclonal

Anti-SHANK3 antibody - ab104695 from Abcam Host Goat Clonality Polyclonal

Anti-SHANK3 antibody - ab188139 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SHANK3 antibody [S69-46] - ab93607 from Abcam Prices $379.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 antibody [S69-46] (Biotin) - ab183422 from Abcam Prices $372.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 antibody [S69-46] (FITC) - ab183420 from Abcam Prices $372.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 antibody [S69-46] (HRP) - ab183421 from Abcam Prices $372.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, APC) - LS-C227764 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Biotin) - LS-C227765 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, FITC) - LS-C227766 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, PE, Atto 594) - LS-C227768 from LifeSpan Bioscience Prices $405.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, RPE) - LS-C227770 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, PerCP) - LS-C227769 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, SA) - LS-C227771 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Atto 390) - LS-C229885 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Atto 565) - LS-C229887 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Atto 594) - LS-C229888 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Atto 488) - LS-C229886 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Atto 655) - LS-C229890 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Atto 633) - LS-C229889 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Anti-SHANK3 Antibody (aa840-857, clone S69-46, Atto 680) - LS-C229891 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S69-46

Search more