SHANK3

Gene Symbol SHANK3
Entrez Gene 85358
Alt Symbol DEL22q13.3, PROSAP2, PSAP2, SCZD15, SPANK-2
Species Human
Gene Type protein-coding
Description SH3 and multiple ankyrin repeat domains 3
Other Description SH3 and multiple ankyrin repeat domains protein 3|proline rich synapse associated protein 2|shank postsynaptic density protein
Swissprots Q8TET3 D7UT47 Q9BYB0
Accessions ABA00478 ADY38945 ADY38946 ADY38947 AFO66271 Q9BYB0 AB051437 BAB33320 AB569469 BAJ09793 AK074038 BAB84864 BC018856 BC045765 BC062987 AAH62987 NM_033517 NP_277052 NM_001080420
Function Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor- mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to
Subcellular Location Cytoplasm {ECO:0000269|PubMed:24132240}. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density {ECO:0000269|PubMed:24132240}. Cell projection, dendritic spine {ECO:0000250}. Note=In neuronal cells, extends into the region subjacent to the postsynaptic density (PSD). {ECO:0000250}.
Tissue Specificity Expressed in the cerebral cortex and the cerebellum.
Top Pathways Glutamatergic synapse

Shank 3 siRNA (h) - sc-42200 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Shank 3 shRNA Plasmid (h) - sc-42200-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Shank 3 shRNA (h) Lentiviral Particles - sc-42200-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19286 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19286 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SHANK3 siRNA (Human) - CRJ3783 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SHANK3 - MBS8204261 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Shank 3 CRISPR/Cas9 KO Plasmid (h) - sc-437313 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shank 3 HDR Plasmid (h) - sc-437313-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shank 3 Double Nickase Plasmid (h) - sc-437313-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shank 3 Double Nickase Plasmid (h2) - sc-437313-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shank 3 CRISPR Activation Plasmid (h) - sc-437313-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shank 3 CRISPR Activation Plasmid (h2) - sc-437313-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shank 3 Lentiviral Activation Particles (h) - sc-437313-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shank 3 Lentiviral Activation Particles (h2) - sc-437313-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SHANK3 shRNA Plasmid (Human) - CHJ3783 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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