Gene Symbol | IGFBP1 |
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Entrez Gene | 3484 |
Alt Symbol | AFBP, IBP1, IGF-BP25, PP12, hIGFBP-1 |
Species | Human |
Gene Type | protein-coding |
Description | insulin-like growth factor binding protein 1 |
Other Description | IBP-1|IGF-binding protein 1|IGFBP-1|alpha-pregnancy-associated endometrial globulin|amniotic fluid binding protein|binding protein-25|binding protein-26|binding protein-28|growth hormone independent-binding protein|insulin-like growth factor-binding protein 1|placental protein 12 |
Swissprots | A4D2F4 P08833 D3DVL9 Q8IYP5 |
Accessions | AAA52783 AAA52784 AAA52785 AAQ96599 AAS07553 CAJ21549 CBH19324 CBX53887 EAL23800 EAW61030 EAW61031 P08833 AF042356 AK314925 BAG37433 AV695706 BC035263 AAH35263 BC057806 AAH57806 BT019685 AAV38491 CA429917 FJ795026 ACO37638 M20841 AAA52540 M31145 AAA52542 X12385 CAA30942 X13405 CAA31771 X15002 CAA33110 Y00856 CAA68770 NM_000596 NP_000587 NM_001013029 |
Function | IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration. {ECO:0000269|PubMed:15972819}. |
Subcellular Location | Secreted. |
IGFBP1 CRISPR/Cas9 KO Plasmid (h) - sc-400915 from Santa Cruz Biotechnology
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IGFBP1 HDR Plasmid (h) - sc-400915-HDR from Santa Cruz Biotechnology
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IGFBP1 Double Nickase Plasmid (h) - sc-400915-NIC from Santa Cruz Biotechnology
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IGFBP1 Double Nickase Plasmid (h2) - sc-400915-NIC-2 from Santa Cruz Biotechnology
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IGFBP1 CRISPR Activation Plasmid (h) - sc-400915-ACT from Santa Cruz Biotechnology
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IGFBP1 CRISPR Activation Plasmid (h2) - sc-400915-ACT-2 from Santa Cruz Biotechnology
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IGFBP1 Lentiviral Activation Particles (h) - sc-400915-LAC from Santa Cruz Biotechnology
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IGFBP1 Lentiviral Activation Particles (h2) - sc-400915-LAC-2 from Santa Cruz Biotechnology
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IGFBP1 siRNA (h) - sc-39584 from Santa Cruz Biotechnology
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IGFBP1 shRNA Plasmid (h) - sc-39584-SH from Santa Cruz Biotechnology
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IGFBP1 shRNA (h) Lentiviral Particles - sc-39584-V from Santa Cruz Biotechnology
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IGFBP-1 RNAi - H00003484-R01 from Novus Biologicals
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MISSION® esiRNA - EHU131401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10520 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10520 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04991 from Sigma-Aldrich
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IGFBP1 siRNA (Human) - CRH2355 from Cohesion Biosciences
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IGFBP1 - MBS8203146 from MyBioSource
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IGFBP1 CRISPR/Cas9 KO Plasmid (h2) - sc-400915-KO-2 from Santa Cruz Biotechnology
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IGFBP1 HDR Plasmid (h2) - sc-400915-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human IGFBP1 (NM_000596.2) - SHH317529 from Creative biogene
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shRNA set against Human IGFBP1(NM_000596.2) - SHL168246 from Creative biogene
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IGFBP1 shRNA Plasmid (Human) - CHH2355 from Cohesion Biosciences
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IGFBP1 miRNA 3'UTR clone - MiUTR1H-04838 from Creative biogene
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