| Gene Symbol | ADGRE5 |
|---|---|
| Entrez Gene | 976 |
| Alt Symbol | CD97, TM7LN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | adhesion G protein-coupled receptor E5 |
| Other Description | CD97 antigen|CD97 molecule|leukocyte antigen CD97|seven transmembrane helix receptor|seven-span transmembrane protein|seven-transmembrane, heterodimeric receptor associated with inflammation |
| Swissprots | Q8NG72 B2RBJ9 O00718 Q8TBQ7 O76101 P48960 A8K7Z4 |
| Accessions | BAC06178 CAA64333 CBX47491 CBX47492 CBX47493 CDM22289 EAW84412 EAW84413 P48960 AI890331 AK097264 BAG53442 AK225655 AK225677 AK292159 BAF84848 AK300343 BAG62088 AK304553 BAG65348 AK308368 AK314697 BAG37246 AU117846 AX775807 CAE11603 AX775809 CAE11604 AX775811 CAE11605 AX775813 CAE11606 AY545551 BC026690 AAH26690 BM545710 CB127827 DC381605 DC414739 U76764 AAB36682 X84700 CAA59173 XM_011528451 XP_011526753 NM_001025160 NP_001020331 NM_001784 NP_001775 NM_078481 NP_510966 |
| Function | Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid. |