| Gene Symbol |
EIF5A2
|
| Entrez Gene |
56648
|
| Alt Symbol |
EIF-5A2, eIF5AII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 5A2
|
| Other Description |
eIF-5A-2|eukaryotic initiation factor 5A|eukaryotic translation initiation factor 5A-2
|
| Swissprots |
Q9GZV4 B2R4V5
|
| Accessions |
AAG23176 EAW78501 Q9GZV4 AK311962 BAG34902 AY205258 AAO18676 AY205259 AAO18677 AY205260 AAO18678 AY205261 AAO18679 BC034420 BC036072 AAH36072 DQ890965 ABM81891 DQ894138 ABM85064 NM_020390 NP_065123
|
| Function |
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in ovarian and colorectal cancer cell lines (at protein level). Highly expressed in testis. Overexpressed in some cancer cells. {ECO:0000269|PubMed:11161802, ECO:0000269|PubMed:16519677}.
|
![Western Blot: eIF5A2 Overexpression Lysate (Adult Normal) [NBL1-10215] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for eIF5A2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8893_eIF5A2%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-10215-img0002.jpg)