Gene Symbol | DOLK |
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Entrez Gene | 22845 |
Alt Symbol | CDG1M, DK, DK1, SEC59, TMEM15 |
Species | Human |
Gene Type | protein-coding |
Description | dolichol kinase |
Other Description | SEC59 homolog|dolichol kinase 1|transmembrane protein 15 |
Swissprots | Q9UPQ8 Q5SRE6 |
Accessions | EAW87849 Q9UPQ8 AB029017 BAA83046 AK225402 AK300180 BAG61959 AY358759 AAQ89119 BC035556 AAH35556 BF056649 JF432695 ADZ15912 NM_014908 NP_055723 |
Function | Involved in the synthesis of the sugar donor Dol-P-Man which is required in the synthesis of N-linked and O-linked oligosaccharides and for that of GPI anchors. {ECO:0000250}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | N-Glycan biosynthesis |
dolichol kinase CRISPR/Cas9 KO Plasmid (h) - sc-411617 from Santa Cruz Biotechnology
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dolichol kinase HDR Plasmid (h) - sc-411617-HDR from Santa Cruz Biotechnology
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dolichol kinase Double Nickase Plasmid (h) - sc-411617-NIC from Santa Cruz Biotechnology
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dolichol kinase Double Nickase Plasmid (h2) - sc-411617-NIC-2 from Santa Cruz Biotechnology
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dolichol kinase CRISPR Activation Plasmid (h) - sc-411617-ACT from Santa Cruz Biotechnology
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dolichol kinase CRISPR Activation Plasmid (h2) - sc-411617-ACT-2 from Santa Cruz Biotechnology
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dolichol kinase Lentiviral Activation Particles (h) - sc-411617-LAC from Santa Cruz Biotechnology
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dolichol kinase Lentiviral Activation Particles (h2) - sc-411617-LAC-2 from Santa Cruz Biotechnology
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dolichol kinase siRNA (h) - sc-92880 from Santa Cruz Biotechnology
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dolichol kinase shRNA Plasmid (h) - sc-92880-SH from Santa Cruz Biotechnology
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dolichol kinase shRNA (h) Lentiviral Particles - sc-92880-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU029061 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7434 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7434 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01293 from Sigma-Aldrich
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DOLK siRNA (Human) - CRH7807 from Cohesion Biosciences
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DOLK - MBS8237912 from MyBioSource
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shRNA set against Human DOLK (NM_014908.3) - SHH280345 from Creative biogene
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shRNA set against Human DOLK(NM_014908.3) - SHH013763 from Creative biogene
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Human DOLK siRNA - orb268309 from Biorbyt
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DOLK shRNA Plasmid (Human) - CHH7807 from Cohesion Biosciences
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DOLK miRNA 3'UTR clone - MiUTR1H-02958 from Creative biogene
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