CYP3A4

Gene Symbol	CYP3A4
Entrez Gene	1576
Alt Symbol	CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 3, subfamily A, polypeptide 4
Other Description	1,8-cineole 2-exo-monooxygenase|P450-III, steroid inducible|albendazole monooxygenase|albendazole sulfoxidase|cytochrome P450 3A3|cytochrome P450 3A4|cytochrome P450 HLp|cytochrome P450 NF-25|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450-PCN1|glucocorticoid-inducible P450|nifedipine oxidase|quinine 3-monooxygenase|taurochenodeoxycholate 6-alpha-hydroxylase
Swissprots	P05184 P08684 Q16757 Q9UK50
Accessions	AAF21034 AAG32290 AAG53948 AAY16980 EAL23866 EAW76635 EAW76636 P08684 AF182273 AAF13598 AJ563375 CAD91343 AJ563376 CAD91645 AJ563377 CAD91345 AK298451 BAG60667 AK298462 BAG60675 AK312967 BAG35806 AY606313 BC069352 BC069418 AAH69418 BC101631 AAI01632 D00003 BAA00001 DA639071 DQ924960 ABI96208 J04449 AAA35747 M13785 AAA35742 M14096 AAA35744 M18907 AAA35745 X12387 CAA30944 XM_011515841 XP_011514143 XM_011515842 XP_011514144 NM_001202855 NP_001189784 NM_017460 NP_059488 NM_001202856 NM_001202857
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. {ECO:0000269|PubMed:11159812}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue Specificity	Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). {ECO:0000269|PubMed:18545703, ECO:0000269|PubMed:19094056, ECO:0000269|PubMed:19359404, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:7894497, ECO:0000269|PubMed:8035341}.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Bile secretion, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse CYP3A4 / Cytochrome P450 3A4 ELISA Kit (Sandwich ELISA) - LS-F7755 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.62 ng/ml Range 1.56-100 ng/ml

Human CYP3A4 / Cytochrome P450 3A4 ELISA Kit (Sandwich ELISA) - LS-F8043 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.313 ng/ml Range 1.56-100 ng/ml

Human CYP3A4 / Cytochrome P450 3A4 ELISA Kit - LS-F11200 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 78 - 5000 pg/ml

Human Cytochrome P450 3A4 ELISA Kit - abx151246 from Abbexa Category ELISA Kit Sensitivity 0.128 ng/ml Range 0.313 ng/ml - 20 ng/ml

Cytochrome P450 3A4 (CYP3A4), Human, ELISA Kit - CSB-EL006439HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Cytochrome P450 3A4 (CYP3A4), Human, ELISA Kit - SED299Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.122ng/mL Range 0.312-20ng/mL

Cytochrome P450 3A4, CYP3A4, Human, ELISA Kit - E0217h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Cytochrome P450 3A4, Human, ELISA Kit - E01C0238 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 1.0-25ng/mL,

CYP3A4 (Human) IP-WB Antibody Pair - H00001576-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human CYP3A4 ELISA Kit - HC0245 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CYP3A4 ELISA Kit - AC0245 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Cytochrome P450 3A4/5 Colorimetric Cell-Based ELISA - CB6140 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

CYP3A4, ELISA Kit - MBS2516116 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.188ng/mL Range 0.313-20ng/mL

Cytochrome P450 3A4, ELISA Kit - MBS032514 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 3A4, ELISA Kit - MBS730400 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 0.1 ng/mL.

Cytochrome P450 3A4, ELISA Kit - MBS736305 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 3A4, ELISA Kit - MBS734266 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Cytochrome P450 3A4, ELISA Kit - MBS075073 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 3A4, ELISA Kit - MBS736837 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 3A4, ELISA Kit - MBS014664 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0ng/ml. Range 3.12 ng/ml - 100 ng/ml.

Cytochrome P450 3A4, ELISA Kit - MBS028755 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 3A4, ELISA Kit - MBS741973 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Cytochrome P450 3A4, ELISA Kit - MBS101722 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 3A4, ELISA Kit - MBS030299 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Cytochrome P450 3A4, ELISA Kit - MBS720221 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

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