CYP3A4

Gene Symbol	CYP3A4
Entrez Gene	1576
Alt Symbol	CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
Species	Human
Gene Type	protein-coding
Description	cytochrome P450, family 3, subfamily A, polypeptide 4
Other Description	1,8-cineole 2-exo-monooxygenase|P450-III, steroid inducible|albendazole monooxygenase|albendazole sulfoxidase|cytochrome P450 3A3|cytochrome P450 3A4|cytochrome P450 HLp|cytochrome P450 NF-25|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450-PCN1|glucocorticoid-inducible P450|nifedipine oxidase|quinine 3-monooxygenase|taurochenodeoxycholate 6-alpha-hydroxylase
Swissprots	P05184 P08684 Q16757 Q9UK50
Accessions	AAF21034 AAG32290 AAG53948 AAY16980 EAL23866 EAW76635 EAW76636 P08684 AF182273 AAF13598 AJ563375 CAD91343 AJ563376 CAD91645 AJ563377 CAD91345 AK298451 BAG60667 AK298462 BAG60675 AK312967 BAG35806 AY606313 BC069352 BC069418 AAH69418 BC101631 AAI01632 D00003 BAA00001 DA639071 DQ924960 ABI96208 J04449 AAA35747 M13785 AAA35742 M14096 AAA35744 M18907 AAA35745 X12387 CAA30944 XM_011515841 XP_011514143 XM_011515842 XP_011514144 NM_001202855 NP_001189784 NM_017460 NP_059488 NM_001202856 NM_001202857
Function	Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. {ECO:0000269|PubMed:11159812}.
Subcellular Location	Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein.
Tissue Specificity	Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). {ECO:0000269|PubMed:18545703, ECO:0000269|PubMed:19094056, ECO:0000269|PubMed:19359404, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:7894497, ECO:0000269|PubMed:8035341}.
Top Pathways	Chemical carcinogenesis, Steroid hormone biosynthesis, Bile secretion, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Cytochrome P450 3A4 peptide - ab106467 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cytochrome P450 3A4 full length protein - ab114327 from Abcam Category Protein Source Wheat germ Species Human

Human Cytochrome P450 3A4 protein fragment - ab114328 from Abcam Category Protein Source Wheat germ Species Human

CYP3A4 / Cytochrome P450 3A4 Antibody Blocking Peptide - LS-E18489 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP3A4 / Cytochrome P450 3A4 Antibody Blocking Peptide - LS-E18490 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP3A4 / Cytochrome P450 3A4 Antibody Blocking Peptide - LS-E26070 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CYP3A4 / Cytochrome P450 3A4 Antibody Blocking Peptide - LS-E9259 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Cytochrome P450 3A4 Protein - H00001576-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Cytochrome P450 3A4 Protein - H00001576-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

CYP3A4-Antibody-Center-Blocking-Peptide - BP7788c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CYP3A4 blocking peptide - GTX89375-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

Goat anti CYP3A4 antibody Immunizing peptide - orb17974 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

CYP3A4 Blocking Peptide - 33R-6117 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

CYP3A4 Blocking Peptide - 33R-4669 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Cytochrome P450 3A4 Blocking Peptide - abx062515 from Abbexa Category Peptide Species Human, Mouse, Rat

Cytochrome P450 3A4/5 Blocking Peptide - abx062516 from Abbexa Category Peptide Species Human

Cytochrome P450 3A4 Peptide - AC21-0898-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CYP3A4 - H00001576-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

CYP3A4 - H00001576-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

CYP3A4 - H00001576-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CYP3A4 - H00001576-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Cytochrome P450 3A4 (CYP3A4), Human - 20-8737 from ARP American Research Products Category Protein Prices $489.00 Sizes 50 µg Source E.coli Species Human

CYP3A4 Peptide - 45-448P from ProSci Category Peptide Prices $175.00 Sizes 100 µg

CYP3A4 fusion protein - Ag13074 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, T-HIS Species Human

Recombinant Human CYP3A4 - CYP3A4-540H from Creative Biomart Category Protein Source Insect cells.

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