| Gene Symbol | CYP3A4 |
|---|---|
| Entrez Gene | 1576 |
| Alt Symbol | CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cytochrome P450, family 3, subfamily A, polypeptide 4 |
| Other Description | 1,8-cineole 2-exo-monooxygenase|P450-III, steroid inducible|albendazole monooxygenase|albendazole sulfoxidase|cytochrome P450 3A3|cytochrome P450 3A4|cytochrome P450 HLp|cytochrome P450 NF-25|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3|cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4|cytochrome P450-PCN1|glucocorticoid-inducible P450|nifedipine oxidase|quinine 3-monooxygenase|taurochenodeoxycholate 6-alpha-hydroxylase |
| Swissprots | P05184 P08684 Q16757 Q9UK50 |
| Accessions | AAF21034 AAG32290 AAG53948 AAY16980 EAL23866 EAW76635 EAW76636 P08684 AF182273 AAF13598 AJ563375 CAD91343 AJ563376 CAD91645 AJ563377 CAD91345 AK298451 BAG60667 AK298462 BAG60675 AK312967 BAG35806 AY606313 BC069352 BC069418 AAH69418 BC101631 AAI01632 D00003 BAA00001 DA639071 DQ924960 ABI96208 J04449 AAA35747 M13785 AAA35742 M14096 AAA35744 M18907 AAA35745 X12387 CAA30944 XM_011515841 XP_011514143 XM_011515842 XP_011514144 NM_001202855 NP_001189784 NM_017460 NP_059488 NM_001202856 NM_001202857 |
| Function | Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4- hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2- exo-monooxygenase. The enzyme also hydroxylates etoposide. {ECO:0000269|PubMed:11159812}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein. Microsome membrane; Single-pass membrane protein. |
| Tissue Specificity | Expressed in prostate and liver. According to some authors, it is not expressed in brain (PubMed:19094056). According to others, weak levels of expression are measured in some brain locations (PubMed:19359404 and PubMed:18545703). Also expressed in epithelium of the small intestine and large intestine, bile duct, nasal mucosa, kidney, adrenal cortex, epithelium of the gastric mucosa with intestinal metaplasia, gallbladder, intercalated ducts of the pancreas, chief cells of the parathyroid and the corpus luteum of the ovary (at protein level). {ECO:0000269|PubMed:18545703, ECO:0000269|PubMed:19094056, ECO:0000269|PubMed:19359404, ECO:0000269|PubMed:2732228, ECO:0000269|PubMed:7894497, ECO:0000269|PubMed:8035341}. |
| Top Pathways | Chemical carcinogenesis, Steroid hormone biosynthesis, Bile secretion, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450 |