CHD3
| Gene Symbol | CHD3 |
|---|---|
| Entrez Gene | 1107 |
| Alt Symbol | Mi-2a, Mi2-ALPHA, ZFH |
| Species | Human |
| Gene Type | protein-coding |
| Description | chromodomain helicase DNA binding protein 3 |
| Other Description | ATP-dependent helicase CHD3|CHD-3|chromodomain-helicase-DNA-binding protein 3|hZFH|mi-2 autoantigen 240 kDa protein|zinc finger helicase|zinc-finger helicase (Snf2-like) |
| Swissprots | Q12873 Q9Y4I0 D3DTQ9 E9PG89 |
| Accessions | EAW90114 EAW90115 EAW90116 Q12873 AF064844 AK096555 AK125928 BAG54266 AK296725 BAG59313 AK296937 BAG59488 AK308362 BC110648 AAI10649 BC156472 AAI56473 BM554923 BX283837 CB851648 U08379 AAC50228 U91543 AAC39923 XM_005256427 XP_005256484 XM_005256428 XP_005256485 XM_005256429 XP_005256486 XM_005256431 XP_005256488 XM_006721423 XP_006721486 XM_006721424 XP_006721487 XM_006721425 XP_006721488 XM_006721427 XP_006721490 XM_006721428 XP_006721491 XM_006721430 XP_006721493 XM_011523628 XP_011521930 XM_011523629 XP_011521931 XM_011523630 XP_011521932 NM_001005271 NP_001005271 NM_001005273 NP_001005273 NM_005852 NP_005843 |
| Function | Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. {ECO:0000269|PubMed:17626165, ECO:0000269|PubMed:9804427}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:17626165}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:17626165}. Note=Associates with centrosomes in interphase and mitosis. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9688266}. |
Mi2-α CRISPR/Cas9 KO Plasmid (h) - sc-408715 from Santa Cruz Biotechnology
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Mi2-α HDR Plasmid (h) - sc-408715-HDR from Santa Cruz Biotechnology
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Mi2-α Double Nickase Plasmid (h) - sc-408715-NIC from Santa Cruz Biotechnology
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Mi2-α Double Nickase Plasmid (h2) - sc-408715-NIC-2 from Santa Cruz Biotechnology
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Mi2-α CRISPR Activation Plasmid (h) - sc-408715-ACT from Santa Cruz Biotechnology
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Mi2-α CRISPR Activation Plasmid (h2) - sc-408715-ACT-2 from Santa Cruz Biotechnology
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Mi2-α Lentiviral Activation Particles (h) - sc-408715-LAC from Santa Cruz Biotechnology
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Mi2-α Lentiviral Activation Particles (h2) - sc-408715-LAC-2 from Santa Cruz Biotechnology
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Mi2α siRNA (h) - sc-37951 from Santa Cruz Biotechnology
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Mi2α shRNA Plasmid (h) - sc-37951-SH from Santa Cruz Biotechnology
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Mi2α shRNA (h) Lentiviral Particles - sc-37951-V from Santa Cruz Biotechnology
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CHD3 RNAi - H00001107-R05 from Novus Biologicals
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MISSION® esiRNA - EHU122631 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6043 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6043 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04924 from Sigma-Aldrich
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CHD3 siRNA (Human) - CRH0789 from Cohesion Biosciences
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CHD3 RNAi - H00001107-R06 from Novus Biologicals
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CHD3 RNAi - H00001107-R04 from Novus Biologicals
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CHD3 - MBS8219425 from MyBioSource
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shRNA set against Human Chd3 (NM_001005273.2) - SHH262853 from Creative biogene
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shRNA set against Human CHD3(NM_001005271.2) - SHG174133 from Creative biogene
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shRNA set against Human CHD3(NM_001005273.2) - SHG174205 from Creative biogene
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shRNA set against Human CHD3(NM_005852.3) - SHG174241 from Creative biogene
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CHD3 shRNA Plasmid (Human) - CHH0789 from Cohesion Biosciences
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