| Gene Symbol |
TSHR
|
| Entrez Gene |
7253
|
| Alt Symbol |
CHNG1, LGR3, hTSHR-I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thyroid stimulating hormone receptor
|
| Other Description |
seven transmembrane helix receptor|thyrotropin receptor|thyrotropin receptor-I, hTSHR-I
|
| Swissprots |
Q9UPH3 Q9ULA3 Q96GT6 Q8TB90 G3V2A9 F5GYU5 Q9P1V4 Q16503 A0PJU7 P16473
|
| Accessions |
AAD31568 AAF09032 AAF26775 AAY27841 BAC05818 CAA40703 EAW81333 P16473 AB209207 BAD92444 AF035261 AAB87990 AK303378 BAG64434 AY429111 AAR07906 BC009237 AAH09237 BC024205 AAH24205 BC063613 AAH63613 BC108653 AAI08654 BC120972 AAI20973 BC120973 AAI20974 BC127628 AAI27629 BC127629 BC141970 AAI41971 BC156779 AAI56780 HQ448048 ADQ32529 M31774 AAA36783 M32215 AAA61236 M73747 AAA70232 R51015 S45272 AAB23390 S49816 AAB24246 S82807 XM_005268037 XP_005268094 XM_005268039 XP_005268096 XM_006720245 XP_006720308 XM_011537119 XP_011535421 NM_000369 NP_000360 NM_001018036 NP_001018046 NM_001142626 NP_001136098
|
| Function |
Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). {ECO:0000269|PubMed:12045258}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in the thyroid. {ECO:0000269|PubMed:2610690}.
|
| Top Pathways |
Autoimmune thyroid disease, Thyroid hormone synthesis, cAMP signaling pathway, Neuroactive ligand-receptor interaction
|
![Western Blot: TSH Receptor Overexpression Lysate (Adult Normal) [NBL1-17361] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TSH Receptor.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/9478_TSH%2520Receptor%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17361-img0002.jpg)