TSHR

Gene Symbol TSHR
Entrez Gene 7253
Alt Symbol CHNG1, LGR3, hTSHR-I
Species Human
Gene Type protein-coding
Description thyroid stimulating hormone receptor
Other Description seven transmembrane helix receptor|thyrotropin receptor|thyrotropin receptor-I, hTSHR-I
Swissprots Q9UPH3 Q9ULA3 Q96GT6 Q8TB90 G3V2A9 F5GYU5 Q9P1V4 Q16503 A0PJU7 P16473
Accessions AAD31568 AAF09032 AAF26775 AAY27841 BAC05818 CAA40703 EAW81333 P16473 AB209207 BAD92444 AF035261 AAB87990 AK303378 BAG64434 AY429111 AAR07906 BC009237 AAH09237 BC024205 AAH24205 BC063613 AAH63613 BC108653 AAI08654 BC120972 AAI20973 BC120973 AAI20974 BC127628 AAI27629 BC127629 BC141970 AAI41971 BC156779 AAI56780 HQ448048 ADQ32529 M31774 AAA36783 M32215 AAA61236 M73747 AAA70232 R51015 S45272 AAB23390 S49816 AAB24246 S82807 XM_005268037 XP_005268094 XM_005268039 XP_005268096 XM_006720245 XP_006720308 XM_011537119 XP_011535421 NM_000369 NP_000360 NM_001018036 NP_001018046 NM_001142626 NP_001136098
Function Receptor for thyrothropin. Plays a central role in controlling thyroid cell metabolism. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Also acts as a receptor for thyrostimulin (GPA2+GPB5). {ECO:0000269|PubMed:12045258}.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in the thyroid. {ECO:0000269|PubMed:2610690}.
Top Pathways Autoimmune thyroid disease, Thyroid hormone synthesis, cAMP signaling pathway, Neuroactive ligand-receptor interaction

TSHR (H-155) - sc-13936 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TSHR (H-155): sc-13936. Western blot analysis of TSHR expression in 293T whole cell lysate.

TSHR (C-20) - sc-7817 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TSHR (A10) - sc-57489 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TSHR (A10): sc-57489. Western blot analysis of TSHR expression in human thyroid tissue extract.

TSHR (A7) - sc-57490 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TSHR (4C1) - sc-32262 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Indirect FCM analysis of GPI-anchored TSHR (Da Costa CR, Johnstone AP. JBC, 1998). Red shaded histogram represents control mouse IgG. Blue line histogram represents TSHR (2C11), sc-32263. Green line histogram representsTSHR (4C1), sc-32262. Kindly provided by Dr. Alan Johnstone, St. George's, University of London.

TSHR (3B12) - sc-53542 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TSHR (3B12): sc-53542. Immunoperoxidase staining of formalin fixed, paraffin-embedded human thyroid gland tissue showing cytoplasmic staining of glandular cells.

TSHR (2C11) - sc-32263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Indirect FCM analysis of GPI-anchored TSHR (Da Costa CR, Johnstone AP. JBC, 1998). Red shaded histogram represents control mouse IgG. Blue line histogram represents TSHR (2C11), sc-32263. Green line histogram representsTSHR (4C1), sc-32262. Kindly provided by Dr. Alan Johnstone, St. George's, University of London.

TSHR (N-19) - sc-7816 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TSHR (N-19): sc-7816. Immunofluorescence staining of methanol-fixed HeLa cells showing membrane localization.

TSHR (A9) - sc-57491 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

TSHR (5G225) - sc-73241 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal

Anti-TSH Receptor antibody - ab202960 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed and paraffin embedded Mouse spleen tissue labeling TSH Receptor using ab202960 at 1/200 dilution, followed by conjugation to the secondary antibody and DAB staining.

Anti-TSH Receptor antibody [28] - ab2812 from Abcam

Prices $378.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 28

Anti-TSH Receptor antibody [4C1] - ab27974 from Abcam

Prices $381.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C1
ab27974 staining TSH Receptor in Human thyroid tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-TSH Receptor antibody [4C1/E1/G8] - ab49702 from Abcam

Prices $379.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal
Clone 4C1/E1/G8
Paraffin section of normal human thyroid gland: immunohistochemical staining for TSH receptor using ab49702 at 1/25 dilution. Note cytoplasmic staining of thyroid epithelial cells.

Anti-TSH Receptor antibody [A10] - ab6048 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A10

Anti-TSH Receptor antibody [A7] - ab6044 from Abcam

Prices $381.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A7
ICC/IF image of ab6044 stained Hek293 cells. The cells were 4% PFA fixed (10 min) and then incubated in 1%BSA / 10% normal Goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab6044, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 Goat anti-Mouse IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-TSH Receptor antibody [A9] - ab6047 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone A9

Anti-TSH Receptor / TSHR Antibody (aa32-41) - LS-C92817 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TSH Receptor / TSHR Antibody (aa277-296) - LS-C92818 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal

Anti-TSH Receptor / TSHR Antibody - LS-C95995 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TSH Receptor / TSHR Antibody (aa251-300) - LS-C30521 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 Cell Lysate

Anti-TSH Receptor / TSHR Antibody (C-Terminus) - LS-C30523 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-TSH Receptor / TSHR Antibody (aa31-80) - LS-C31952 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Jurkat Cell Lysate

Anti-TSH Receptor / TSHR Antibody (clone TS106) - LS-C191496 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone TS106

Anti-TSH Receptor / TSHR Antibody - LS-C285707 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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