Gene Symbol | CFHR1 |
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Entrez Gene | 3078 |
Alt Symbol | CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2 |
Species | Human |
Gene Type | protein-coding |
Description | complement factor H-related 1 |
Other Description | FHR-1|H factor (complement)-like 1|H factor (complement)-like 2|H-factor-like 1|H36|complement factor H-related 1 pseudogene|complement factor H-related protein 1|h factor-like protein 1 |
Swissprots | Q03591 Q3B774 Q9UJ17 A8K465 |
Accessions | CBN73473 Q03591 AI075816 AK290830 BAF83519 AK311681 BC016755 AAH16755 BC107771 AAI07772 BG568702 DQ892762 ABM83688 DQ896007 ABM86991 M65292 AAA35946 M65293 AAA35947 X56209 CAA39666 X56210 CAA39667 XM_006711284 XP_006711347 XM_011509457 XP_011507759 NM_002113 NP_002104 |
Function | Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. {ECO:0000269|PubMed:23487775}. |
Subcellular Location | Secreted. |
Tissue Specificity | Expressed by the liver and secreted in plasma. |
FHR-1 CRISPR/Cas9 KO Plasmid (h) - sc-416510 from Santa Cruz Biotechnology
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FHR-1 HDR Plasmid (h) - sc-416510-HDR from Santa Cruz Biotechnology
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FHR-1 Double Nickase Plasmid (h) - sc-416510-NIC from Santa Cruz Biotechnology
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FHR-1 Double Nickase Plasmid (h2) - sc-416510-NIC-2 from Santa Cruz Biotechnology
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FHR-1 CRISPR Activation Plasmid (h) - sc-416510-ACT from Santa Cruz Biotechnology
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FHR-1 CRISPR Activation Plasmid (h2) - sc-416510-ACT-2 from Santa Cruz Biotechnology
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FHR-1 Lentiviral Activation Particles (h) - sc-416510-LAC from Santa Cruz Biotechnology
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FHR-1 Lentiviral Activation Particles (h2) - sc-416510-LAC-2 from Santa Cruz Biotechnology
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FHR-1 siRNA (h) - sc-42879 from Santa Cruz Biotechnology
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FHR-1 shRNA Plasmid (h) - sc-42879-SH from Santa Cruz Biotechnology
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FHR-1 shRNA (h) Lentiviral Particles - sc-42879-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU115071 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6000 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6000 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00847 from Sigma-Aldrich
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CFHR1 siRNA (Human) - CRH2097 from Cohesion Biosciences
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CFHR1 - MBS8217531 from MyBioSource
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shRNA set against Human CFHR1 (NM_002113.2) - SHH262433 from Creative biogene
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Human CFHR1 siRNA - orb262599 from Biorbyt
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CFHR1 shRNA Plasmid (Human) - CHH2097 from Cohesion Biosciences
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CFHR1 miRNA 3'UTR clone - MiUTR1H-02073 from Creative biogene
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