| Gene Symbol |
IL27
|
| Entrez Gene |
246778
|
| Alt Symbol |
IL-27, IL-27A, IL27A, IL27p28, IL30, p28
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
interleukin 27
|
| Other Description |
IL-27 p28 subunit|IL-27 subunit alpha|IL-27-A|IL27-A|interleukin 30|interleukin-27 subunit alpha|interleukin-30
|
| Swissprots |
Q8NEV9 Q6P676 A0N0L2
|
| Accessions |
ABK41903 CCA63967 EAW52277 Q8NEV9 AY099296 AAM34498 BC062422 AAH62422 HQ447563 ADQ32049 XM_011545780 XP_011544082 NM_145659 NP_663634
|
| Function |
Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:12121660}. Note=Does not seem to be secreted without coexpression of EBI3.
|
| Tissue Specificity |
Expressed in monocytes and in placenta. {ECO:0000269|PubMed:12121660}.
|
