| Gene Symbol | IL27 |
|---|---|
| Entrez Gene | 246778 |
| Alt Symbol | IL-27, IL-27A, IL27A, IL27p28, IL30, p28 |
| Species | Human |
| Gene Type | protein-coding |
| Description | interleukin 27 |
| Other Description | IL-27 p28 subunit|IL-27 subunit alpha|IL-27-A|IL27-A|interleukin 30|interleukin-27 subunit alpha|interleukin-30 |
| Swissprots | Q8NEV9 Q6P676 A0N0L2 |
| Accessions | ABK41903 CCA63967 EAW52277 Q8NEV9 AY099296 AAM34498 BC062422 AAH62422 HQ447563 ADQ32049 XM_011545780 XP_011544082 NM_145659 NP_663634 |
| Function | Associates with EBI3 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR which appears to be required but not sufficient for IL-27-mediated signal transduction. IL-27 potentiate the early phase of TH1 response and suppress TH2 and TH17 differentiation. It induces the differentiation of TH1 cells via two distinct |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12121660}. Note=Does not seem to be secreted without coexpression of EBI3. |
| Tissue Specificity | Expressed in monocytes and in placenta. {ECO:0000269|PubMed:12121660}. |
IL-27 CRISPR/Cas9 KO Plasmid (h) - sc-405587 from Santa Cruz Biotechnology
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IL-27 HDR Plasmid (h) - sc-405587-HDR from Santa Cruz Biotechnology
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IL-27 Double Nickase Plasmid (h) - sc-405587-NIC from Santa Cruz Biotechnology
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IL-27 Double Nickase Plasmid (h2) - sc-405587-NIC-2 from Santa Cruz Biotechnology
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IL-27 CRISPR Activation Plasmid (h) - sc-405587-ACT from Santa Cruz Biotechnology
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IL-27 CRISPR Activation Plasmid (h2) - sc-405587-ACT-2 from Santa Cruz Biotechnology
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IL-27 Lentiviral Activation Particles (h) - sc-405587-LAC from Santa Cruz Biotechnology
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IL-27 Lentiviral Activation Particles (h2) - sc-405587-LAC-2 from Santa Cruz Biotechnology
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IL-27 siRNA (h) - sc-72184 from Santa Cruz Biotechnology
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IL-27 shRNA Plasmid (h) - sc-72184-SH from Santa Cruz Biotechnology
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IL-27 shRNA (h) Lentiviral Particles - sc-72184-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN10617 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10617 from Sigma-Aldrich
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IL27 siRNA (Human) - CRJ6627 from Cohesion Biosciences
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IL27 - MBS8213828 from MyBioSource
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shRNA set against Human IL27 (NM_145659.3) - SHH318801 from Creative biogene
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shRNA set against Human IL27(NM_145659.3) - SHL172990 from Creative biogene
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Human IL27 siRNA - orb277128 from Biorbyt
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IL27 shRNA Plasmid (Human) - CHJ6627 from Cohesion Biosciences
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IL27 miRNA 3'UTR clone - MiUTR1H-04913 from Creative biogene
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