| Gene Symbol |
CACNA1I
|
| Entrez Gene |
8911
|
| Alt Symbol |
Cav3.3, ca(v)3.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calcium channel, voltage-dependent, T type, alpha 1I subunit
|
| Other Description |
calcium channel, voltage-dependent, alpha 1I subunit|voltage-dependent T-type calcium channel subunit alpha-1I|voltage-gated calcium channel subunit alpha Cav3.3
|
| Swissprots |
B0QY13 O95504 Q9UNE6 B0QY12 Q9UH30 B0QY14 Q9NZC8 Q5JZ88 Q9UH15 Q8NFX6 Q9P0X4 Q9ULU9 Q7Z6S9
|
| Accessions |
EAW60345 EAW60346 EAW60347 EAW60348 EAW60349 EAW60350 EAW60351 Q9P0X4 AB032946 BAA86434 AF129133 AAD45251 AF142567 AAF25722 AF211189 AAF44626 AF393329 AAM67414 BC042972 N52765 XM_011530480 XP_011528782 XM_011530481 XP_011528783 NM_001003406 NP_001003406 NM_021096 NP_066919
|
| Function |
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. Isoform alpha-1I gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H (By s
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Brain specific.
|
| Top Pathways |
MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment
|