| Gene Symbol |
NGEF
|
| Entrez Gene |
25791
|
| Alt Symbol |
ARHGEF27, EPHEXIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuronal guanine nucleotide exchange factor
|
| Other Description |
eph-interacting exchange protein|ephexin-1
|
| Swissprots |
E9PC42 Q8N5V2 B4DMB8 Q9NQD6 Q53ST7 B9A045 Q53QQ4 Q6GMQ5
|
| Accessions |
AAX93288 AAY24359 EAW71024 EAW71025 EAW71026 Q8N5V2 AJ238899 CAC00686 AK293203 BAG56743 AK297390 BAG59830 AK298315 BAG60569 AK300953 BAG62581 BC031573 AAH31573 BC073962 AAH73962 BX431262 DB242442 DC388448 DQ890843 ABM81769 DQ893998 ABM84924 HQ292143 XM_011510923 XP_011509225 XM_011510924 XP_011509226 XM_011510925 XP_011509227 NM_001114090 NP_001107562 NM_019850 NP_062824
|
| Function |
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. {ECO:0000269|PubMed:10777665}.
|
| Top Pathways |
Axon guidance
|