NGEF

Gene Symbol	NGEF
Entrez Gene	25791
Alt Symbol	ARHGEF27, EPHEXIN
Species	Human
Gene Type	protein-coding
Description	neuronal guanine nucleotide exchange factor
Other Description	eph-interacting exchange protein|ephexin-1
Swissprots	E9PC42 Q8N5V2 B4DMB8 Q9NQD6 Q53ST7 B9A045 Q53QQ4 Q6GMQ5
Accessions	AAX93288 AAY24359 EAW71024 EAW71025 EAW71026 Q8N5V2 AJ238899 CAC00686 AK293203 BAG56743 AK297390 BAG59830 AK298315 BAG60569 AK300953 BAG62581 BC031573 AAH31573 BC073962 AAH73962 BX431262 DB242442 DC388448 DQ890843 ABM81769 DQ893998 ABM84924 HQ292143 XM_011510923 XP_011509225 XM_011510924 XP_011509226 XM_011510925 XP_011509227 NM_001114090 NP_001107562 NM_019850 NP_062824
Function	Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}. Cell projection, growth cone {ECO:0000250}. Note=Associated with membranes. Localizes to axonal growth cones (By similarity). {ECO:0000250}.
Tissue Specificity	Highly expressed in brain specifically in caudate nucleus and to a lower extent in amygdala and hippocampus. Also detected in lung. {ECO:0000269|PubMed:10777665}.
Top Pathways	Axon guidance

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Ephexin-1 protein fragment - ab161782 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human NGEF Protein - H00025791-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NGEF - H00025791-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NGEF - H00025791-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

NGEF fusion protein - ag3967 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

NGEF fusion protein - ag6929 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Ephexin-1(NGEF) - CSB-YP850809HU CSB-EP850809HU CSB-BP850809HU CSB-MP850809HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Ephexin-1 (C-terminal region) - EX2825 from ECM Biosciences Category Peptide Prices $55.00 Sizes 50 μg

NGEF (transcript variant 1) - TP306775 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

NGEF Recombinant Protein Antigen - NBP1-88820PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

NGEF-Blocking-Peptide-N-term - BP21608a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NGEF-Blocking-Peptide-C-term - BP21607b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NGEF Peptide, Human - M34GP10359H from Creative Peptides Category Peptide Source Synthetic. Species Human

NGEF Antibody - SH-A14008 from Novatein Biosciences Prices $315.00 Sizes 100 µl Species Human, Mouse, Rat

Ephexin-1 (NGEF), Recombinant Protein - MBS1428489 from MyBioSource Category Protein Prices $1,515.00, $1,515.00, $1,745.00, $1,745.00, $2,600.00, $2,600.00, $3,040.00, $3,040.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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