| Gene Symbol | PMM1 |
|---|---|
| Entrez Gene | 5372 |
| Alt Symbol | Sec53 |
| Species | Human |
| Gene Type | protein-coding |
| Description | phosphomannomutase 1 |
| Other Description | PMM 1|PMMH-22|brain glucose-1,6-bisphosphatase |
| Swissprots | A8K003 Q92871 Q92586 |
| Accessions | EAW60443 EAW60444 Q92871 AK094811 AK130449 AK289368 BAF82057 AK316580 BAG38168 BC010855 AAH10855 BC016818 AAH16818 CR456544 CAG30430 CU013144 CAK54575 CU013432 CAK54874 D87810 BAA13460 U62526 AAC51117 U86070 AAC00023 XM_005261638 XP_005261695 XM_005261641 XP_005261698 XM_005261642 XP_005261699 XM_011530229 XP_011528531 XM_011530230 XP_011528532 XM_011530231 XP_011528533 XM_011530232 XP_011528534 NM_002676 NP_002667 |
| Function | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle. |
| Top Pathways | Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism |