Gene Symbol | PMM1 |
---|---|
Entrez Gene | 5372 |
Alt Symbol | Sec53 |
Species | Human |
Gene Type | protein-coding |
Description | phosphomannomutase 1 |
Other Description | PMM 1|PMMH-22|brain glucose-1,6-bisphosphatase |
Swissprots | A8K003 Q92871 Q92586 |
Accessions | EAW60443 EAW60444 Q92871 AK094811 AK130449 AK289368 BAF82057 AK316580 BAG38168 BC010855 AAH10855 BC016818 AAH16818 CR456544 CAG30430 CU013144 CAK54575 CU013432 CAK54874 D87810 BAA13460 U62526 AAC51117 U86070 AAC00023 XM_005261638 XP_005261695 XM_005261641 XP_005261698 XM_005261642 XP_005261699 XM_011530229 XP_011528531 XM_011530230 XP_011528532 XM_011530231 XP_011528533 XM_011530232 XP_011528534 NM_002676 NP_002667 |
Function | Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}. |
Subcellular Location | Cytoplasm. |
Tissue Specificity | Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle. |
Top Pathways | Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism |
PMM1 CRISPR/Cas9 KO Plasmid (h) - sc-407149 from Santa Cruz Biotechnology
|
||||||||
PMM1 HDR Plasmid (h) - sc-407149-HDR from Santa Cruz Biotechnology
|
||||||||
PMM1 Double Nickase Plasmid (h) - sc-407149-NIC from Santa Cruz Biotechnology
|
||||||||
PMM1 Double Nickase Plasmid (h2) - sc-407149-NIC-2 from Santa Cruz Biotechnology
|
||||||||
PMM1 CRISPR Activation Plasmid (h) - sc-407149-ACT from Santa Cruz Biotechnology
|
||||||||
PMM1 CRISPR Activation Plasmid (h2) - sc-407149-ACT-2 from Santa Cruz Biotechnology
|
||||||||
PMM1 Lentiviral Activation Particles (h) - sc-407149-LAC from Santa Cruz Biotechnology
|
||||||||
PMM1 Lentiviral Activation Particles (h2) - sc-407149-LAC-2 from Santa Cruz Biotechnology
|
||||||||
PMM1 siRNA (h) - sc-76177 from Santa Cruz Biotechnology
|
||||||||
PMM1 shRNA Plasmid (h) - sc-76177-SH from Santa Cruz Biotechnology
|
||||||||
PMM1 shRNA (h) Lentiviral Particles - sc-76177-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17029 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17029 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03181 from Sigma-Aldrich
|
||||||||
PMM1 siRNA (Human) - CRH3607 from Cohesion Biosciences
|
||||||||
PMM1 shRNA Plasmid (Human) - CHH3607 from Cohesion Biosciences
|
||||||||
PMM1 miRNA 3'UTR clone - MiUTR3H-04413 from Creative biogene
|