| Gene Symbol |
PMM1
|
| Entrez Gene |
5372
|
| Alt Symbol |
Sec53
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphomannomutase 1
|
| Other Description |
PMM 1|PMMH-22|brain glucose-1,6-bisphosphatase
|
| Swissprots |
A8K003 Q92871 Q92586
|
| Accessions |
EAW60443 EAW60444 Q92871 AK094811 AK130449 AK289368 BAF82057 AK316580 BAG38168 BC010855 AAH10855 BC016818 AAH16818 CR456544 CAG30430 CU013144 CAK54575 CU013432 CAK54874 D87810 BAA13460 U62526 AAC51117 U86070 AAC00023 XM_005261638 XP_005261695 XM_005261641 XP_005261698 XM_005261642 XP_005261699 XM_011530229 XP_011528531 XM_011530230 XP_011528532 XM_011530231 XP_011528533 XM_011530232 XP_011528534 NM_002676 NP_002667
|
| Function |
Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain. {ECO:0000269|PubMed:16540464}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
|
| Top Pathways |
Amino sugar and nucleotide sugar metabolism, Fructose and mannose metabolism
|
