Gene Symbol | CRTAM |
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Entrez Gene | 56253 |
Alt Symbol | CD355 |
Species | Human |
Gene Type | protein-coding |
Description | cytotoxic and regulatory T cell molecule |
Other Description | class I MHC restricted T cell associated molecule|class-I MHC-restricted T cell associated molecule|class-I MHC-restricted T-cell-associated molecule|cytotoxic and regulatory T-cell molecule |
Swissprots | Q6IRX2 O95727 Q59EI1 |
Accessions | CCF77045 EAW67532 O95727 AB209830 BAD93067 AF001622 AAC80267 AK293470 BAG56963 AK313578 BAG36349 BC070266 AAH70266 BX118379 CA309993 CK004240 DC305734 HQ447587 ADQ32073 XM_011542900 XP_011541202 NM_001304782 NP_001291711 NM_019604 NP_062550 |
Function | Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. {ECO:0000250|UniProtKB:Q149L7, ECO:0000269|PubMed:15811952}. |
Subcellular Location | Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}. |
Tissue Specificity | In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. {ECO:0000269|PubMed:10811014, ECO:0000269|PubMed:15811952, ECO:0000269|PubMed:16300832}. |
Human CRTAM full length protein - ab163368 from Abcam
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Human CRTAM protein fragment - ab151374 from Abcam
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Human CRTAM protein fragment - ab201521 from Abcam
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CRTAM Antibody Blocking Peptide - LS-E17849 from LifeSpan Bioscience
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CRTAM Recombinant Protein - H00056253-P01 from Novus Biologicals
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Recombinant Human CRTAM Protein - H00056253-G01 from Novus Biologicals
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Recombinant Human CRTAM Fc Chimera, CF - 1695-CR-050 from R&D Systems
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Human CRTAM His tag protein - orb83932 from Biorbyt
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Human CRTAM protein - orb49347 from Biorbyt
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CRTAM - H00056253-G01 from Acris Antibodies
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CRTAM - H00056253-P01-10 from Acris Antibodies
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CRTAM - H00056253-P01-25 from Acris Antibodies
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Cytotoxic and Regulatory T-Cell Molecule, CRTAM, Human, Recombinant - 19-C331 from ARP American Research Products
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CRTAM fusion protein - ag9956 from Proteintech Group
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CRTAM fusion protein - ag9945 from Proteintech Group
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Recombinant Human CRTAM Protein - BP001651-C331 from Syd Labs
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Recombinant Human CRTAM, His tagged - CRTAM-3236H from Creative Biomart
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Recombinant Human CRTAM, GST-tagged - CRTAM-11591H from Creative Biomart
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Recombinant Human CRTAM, Fc Chimera - CRTAM-1092H from Creative Biomart
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CRTAM - PN201319 from Elabscience
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Human CRTAM Protein (His Tag) - 11975-H08H-50 from Sino Biological
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Recombinant Human Cytotoxic and regulatory T-cell molecule(CRTAM) - CSB-YP005998HU CSB-EP005998HU CSB-BP005998HU CSB-MP005998HU from Cusabio
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CRTAM (18-287, His-tag) - AR51971PU-N from Acris Antibodies
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CRTAM (18-287, His-tag) - AR51971PU-S from Acris Antibodies
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Recombinant Human CRTAM Fc Chimera Protein, CF - 1695-CR from R&D Systems
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