| Gene Symbol |
FAM132A
|
| Entrez Gene |
388581
|
| Alt Symbol |
C1QDC2, C1QTNF12, CTRP12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
family with sequence similarity 132, member A
|
| Other Description |
C1q domain containing 2|C1q/TNF-related protein 12|adipolin|adipose-derived insulin-sensitizing factor|complement C1q tumor necrosis factor-related protein 12|protein FAM132A
|
| Swissprots |
Q5T7M4 Q5EBL5
|
| Accessions |
Q5T7M4 AW873053 BC089443 AAH89443 XM_011541435 XP_011539737 XM_011541436 XP_011539738 XM_011541437 XP_011539739 NM_001014980 NP_001014980
|
| Function |
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Adipolin fCTRP12: Secreted.
|
| Tissue Specificity |
Predominantly expressed by adipose tissues. {ECO:0000269|PubMed:22275362}.
|