Gene Symbol |
BCL9L
|
Entrez Gene |
283149
|
Alt Symbol |
BCL9-2, DLNB11
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
B-cell CLL/lymphoma 9-like
|
Other Description |
B-cell CLL/lymphoma 9-like protein|B-cell lymphoma 9-like protein|BCL9-like protein|nuclear co-factor of beta-catenin signalling|protein BCL9-2
|
Swissprots |
Q6ZWK2 Q86UU0 A1A4C1 Q67FY1 Q6ZWJ0
|
Accessions |
EAW67418 Q86UU0 AB094091 BAC76045 AK122650 BAC85500 AK122882 BAC85512 AY296059 AAQ62697 BC033257 AAH33257 BC156197 AAI56198 XM_005271511 XP_005271568 XM_005271512 XP_005271569 XM_005271513 XP_005271570 XM_006718815 XP_006718878 XM_011542756 XP_011541058 NM_182557 NP_872363
|
Function |
Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity). {ECO:0000250}.
|
Subcellular Location |
Nucleus {ECO:0000269|PubMed:17129358, ECO:0000269|PubMed:17309600}.
|
Tissue Specificity |
Expressed in breast, ductal and invasive ductal carcinomas of the breast, sporadic colorectal adenomas and carcinomas (at protein level). Expressed in fetal brain. Expressed in lung, amygdala, eye, prostate, pancreatic and prostate cancers, head and neck tumors and embryonal tumor. {ECO:0000269|PubMed:12964048, ECO:0000269|PubMed:17129358, ECO:0000269|PubMed:17309600}.
|