| Gene Symbol |
Pde3b
|
| Entrez Gene |
18576
|
| Alt Symbol |
9830102A01Rik, AI847709
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
phosphodiesterase 3B, cGMP-inhibited
|
| Other Description |
CGI-PDE B|CGIPDE1|cGMP-inhibited 3',5'-cyclic phosphodiesterase B|cyclic GMP-inhibited phosphodiesterase B
|
| Swissprots |
Q61409 Q9Z1J9 Q8CIX5
|
| Accessions |
EDL17069 EDL17070 EDL17071 Q61409 AF547435 AAN52086 AJ132271 CAA10639 AK036412 AK044183 AK142889 BAE25219 AV270888 BB627812 BB663310 BC169298 BC169299 BC169300 BU613166 BY745829 CJ058099 CJ299201 X95521 CAA64775 XM_006507438 XP_006507501 XM_006507439 XP_006507502 NM_011055 NP_035185
|
| Function |
Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Abundant in adipose tissues.
|
| Top Pathways |
Insulin signaling pathway, Progesterone-mediated oocyte maturation, Morphine addiction, cGMP-PKG signaling pathway, cAMP signaling pathway
|
![All lanes : Anti-PDE3B antibody [SMCP3B] (ab95814) at 2 µg/mlLane 1 : Mouse heart cell lysateLane 2 : Mouse lymph node cell lysateSecondaryAnti-Rat IgG HRPPerformed under reducing conditions.](http://www.bioprodhub.com/system/product_images/ab_products/2/sub_4/8926_PDE3B-Primary-antibodies-ab95814-1.JPG)
![Western Blot: PDE3B Antibody (SMCP3B) [NBP1-43333] - Lysates prepared from mouse heart (lane 1) or lymph node cells (lane 2) were run under reducing conditions on a 3-8% Tris-Acetate gel. The membrane was probed with 2 ug/mL of Anti-Mouse PDE3B Purified, followed by Anti-Rat IgG HRP.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/17466_PDE3B%2520Antibody%2520(SMCP3B)-Western%2520Blot-NBP1-43333-img0002.jpg)
