| Gene Symbol |
GNG2
|
| Entrez Gene |
54331
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
guanine nucleotide binding protein (G protein), gamma 2
|
| Other Description |
g gamma-I|guanine nucleotide binding protein gamma 2|guanine nucleotide-binding protein G(I)/G(O) gamma-2 subunit|guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
|
| Swissprots |
Q5JPE2 Q6P9A9 P59768
|
| Accessions |
EAW65663 EAW65664 EAW65665 P59768 AB074180 AF130106 AAG35531 AF493870 AAM12584 AK001024 AK026424 AK026425 AK092371 AK307171 AK311334 AL832878 CAI46198 BC020774 AAH20774 BC041446 BC060856 AAH60856 BE245271 BQ025819 DA226565 DA322879 DA785895 DC318652 XM_006720173 XP_006720236 XM_011536845 XP_011535147 XM_011536846 XP_011535148 NM_001243773 NP_001230702 NM_001243774 NP_001230703 NM_053064 NP_444292
|
| Function |
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}; Cytoplasmic side {ECO:0000305}.
|
| Tissue Specificity |
Expressed in fetal tissues, including testis, adrenal gland, brain, white blood cells and brain. {ECO:0000269|PubMed:10833460}.
|
| Top Pathways |
Dopaminergic synapse, Morphine addiction, Glutamatergic synapse, PI3K-Akt signaling pathway, GABAergic synapse
|
![Western Blot: GNG2 Overexpression Lysate (Adult Normal) [NBL1-11174] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GNG2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9432_GNG2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11174-img0002.jpg)