Gene Symbol | FIGNL1 |
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Entrez Gene | 63979 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | fidgetin-like 1 |
Other Description | fidgetin-like protein 1 |
Swissprots | Q9H8P1 Q6PIW4 Q86V18 Q8ND59 Q9H917 D3DVM6 |
Accessions | AAS01996 EAL23899 EAW60975 EAW60976 Q6PIW4 AK023142 BAB14426 AK023411 BAB14567 AK027537 BAG51338 AK308136 AL834387 CAD39050 BC027856 BC051867 AAH51867 BU166325 BU741583 BX342197 DA114757 DA121143 DA121992 DA433617 DA798223 DA812999 DB067077 EU832584 ACE86986 XM_005271783 XP_005271840 XM_011515469 XP_011513771 XM_011515470 XP_011513772 XM_011515471 XP_011513773 XM_011515472 XP_011513774 NM_001042762 NP_001036227 NM_001287492 NP_001274421 NM_001287493 NP_001274422 NM_001287494 NP_001274423 NM_001287495 NP_001274424 NM_001287496 NP_001274425 NM_022116 NP_071399 |
Function | Involved in DNA double-strand break (DBS) repair via homologous recombination (HR). Recruited at DSB sites independently of BRCA2, RAD51 and RAD51 paralogs in a H2AX- dependent manner. May regulate osteoblast proliferation and differentiation. {ECO:0000269|PubMed:23754376}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:23754376}. Note=Together with RAD51 and a subset of H2A histone proteins, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) treatment. |
FIGNL1 CRISPR/Cas9 KO Plasmid (h) - sc-410087 from Santa Cruz Biotechnology
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FIGNL1 HDR Plasmid (h) - sc-410087-HDR from Santa Cruz Biotechnology
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FIGNL1 Double Nickase Plasmid (h) - sc-410087-NIC from Santa Cruz Biotechnology
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FIGNL1 Double Nickase Plasmid (h2) - sc-410087-NIC-2 from Santa Cruz Biotechnology
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FIGNL1 CRISPR Activation Plasmid (h) - sc-410087-ACT from Santa Cruz Biotechnology
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FIGNL1 CRISPR Activation Plasmid (h2) - sc-410087-ACT-2 from Santa Cruz Biotechnology
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FIGNL1 Lentiviral Activation Particles (h) - sc-410087-LAC from Santa Cruz Biotechnology
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FIGNL1 Lentiviral Activation Particles (h2) - sc-410087-LAC-2 from Santa Cruz Biotechnology
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FIGNL1 siRNA (h) - sc-89427 from Santa Cruz Biotechnology
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FIGNL1 shRNA Plasmid (h) - sc-89427-SH from Santa Cruz Biotechnology
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FIGNL1 shRNA (h) Lentiviral Particles - sc-89427-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU067051 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8696 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8696 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08304 from Sigma-Aldrich
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FIGNL1 siRNA (Human) - CRJ1891 from Cohesion Biosciences
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FIGNL1 - MBS8236886 from MyBioSource
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shRNA set against Human FIGNL1 (NM_022116.3) - SHH295033 from Creative biogene
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shRNA set against Human FIGNL1(NM_001042762.1) - SHH059951 from Creative biogene
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FIGNL1 shRNA Plasmid (Human) - CHJ1891 from Cohesion Biosciences
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FIGNL1 miRNA 3'UTR clone - MiUTR3H-14933 from Creative biogene
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FIGNL1 miRNA 3'UTR clone - MiUTR3H-14934 from Creative biogene
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