AGPAT3
| Gene Symbol | AGPAT3 |
|---|---|
| Entrez Gene | 56894 |
| Alt Symbol | LPAAT-GAMMA1, LPAAT3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | 1-acylglycerol-3-phosphate O-acyltransferase 3 |
| Other Description | 1-AGP acyltransferase 3|1-AGPAT 3|1-acyl-sn-glycerol-3-phosphate acyltransferase gamma|lysophosphatidic acid acyltransferase gamma|lysophosphatidic acid acyltransferase-gamma1 |
| Swissprots | Q8N3Q7 Q6ZUC6 Q3ZCU2 Q9NRZ6 Q6UWP6 D3DSL2 Q9NRZ7 |
| Accessions | EAX09461 EAX09462 EAX09463 EAX09464 EAX09465 Q9NRZ7 AB040138 BAB18943 AF156774 AAF80336 AF156775 AAF80337 AK026135 AK074300 BAB85042 AK125804 BAC86299 AK300562 BAG62268 AL109795 AL355720 AL355721 AL832919 CAD38635 AY358704 AAQ89067 BC004219 BC004413 BC011971 AAH11971 BC013167 BC026047 BC040603 AAH40603 BC063552 AAH63552 BM083518 BM476336 CD672915 HQ447507 ADQ31993 XM_005261160 XP_005261217 XM_006724029 XP_006724092 XM_006724030 XP_006724093 XM_006724031 XP_006724094 XM_011529660 XP_011527962 XM_011529661 XP_011527963 XM_011529662 XP_011527964 XM_011529663 XP_011527965 XM_011529664 XP_011527966 XM_011529665 XP_011527967 XM_011529666 XP_011527968 NM_001037553 NP_001032642 NM_020132 NP_064517 |
| Function | Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the sn-2 position of the glycerol backbone. Acts on LPA containing saturated or unsaturated fatty acids C16:0-C20:4 at the sn-1 position using C18:1, C20:4 or C18:2-CoA as the acyl donor. Also acts on lysophosphatidylcholine, lysophosphatidylinositol and lysophosphatidylserine using C18:1 or C20:4-CoA. {ECO:0000269|PubMed:21173190}. |
| Subcellular Location | Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope. |
| Tissue Specificity | Widely expressed with highest levels in testis, pancreas and kidney, followed by spleen, lung, adipose tissue and liver. {ECO:0000269|PubMed:21173190}. |
| Top Pathways | Glycerolipid metabolism, Glycerophospholipid metabolism |
LPAAT-γ CRISPR/Cas9 KO Plasmid (h) - sc-406574 from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ HDR Plasmid (h) - sc-406574-HDR from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ Double Nickase Plasmid (h) - sc-406574-NIC from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ Double Nickase Plasmid (h2) - sc-406574-NIC-2 from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ CRISPR Activation Plasmid (h) - sc-406574-ACT from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ CRISPR Activation Plasmid (h2) - sc-406574-ACT-2 from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ Lentiviral Activation Particles (h) - sc-406574-LAC from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ Lentiviral Activation Particles (h2) - sc-406574-LAC-2 from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ siRNA (h) - sc-91413 from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ shRNA Plasmid (h) - sc-91413-SH from Santa Cruz Biotechnology
|
||||||||
LPAAT-γ shRNA (h) Lentiviral Particles - sc-91413-V from Santa Cruz Biotechnology
|
||||||||
AGPAT3 RNAi - H00056894-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU081811 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN2950 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2950 from Sigma-Aldrich
|
||||||||
AGPAT3 siRNA (Human) - CRJ1200 from Cohesion Biosciences
|
||||||||
AGPAT3 RNAi - H00056894-R02 from Novus Biologicals
|
||||||||
AGPAT3 - MBS8210168 from MyBioSource
|
||||||||
shRNA set against Human AGPAT3 (NM_020132.4) - SHH233346 from Creative biogene
|
||||||||
shRNA set against Human AGPAT3(NM_001037553.1) - SHG045731 from Creative biogene
|
||||||||
Human AGPAT3 siRNA - orb271701 from Biorbyt
|
||||||||
AGPAT3 shRNA Plasmid (Human) - CHJ1200 from Cohesion Biosciences
|
||||||||
AGPAT3 miRNA 3'UTR clone - MiUTR1H-00240 from Creative biogene
|