TARDBP

Gene Symbol	TARDBP
Entrez Gene	23435
Alt Symbol	ALS10, TDP-43
Species	Human
Gene Type	protein-coding
Description	TAR DNA binding protein
Other Description	TAR DNA-binding protein 43|TAR DNA-binding protein-43
Swissprots	E2PU12 A4GUK4 Q13148 B4DJ45 Q6FI92 Q53H27 A4GUK5 Q96DJ0 A4GUK6 B2R629
Accessions	CBF67564 CBI68017 CBU92437 EAW71669 EAW71670 EAW71671 EAW71672 EAW71673 Q13148 AF311304 AAG47782 AK222754 BAD96474 AK295920 BAG58707 AK299454 BAG61425 AK312416 BAG35326 AL045296 AL050265 CAB43367 AM392916 CAL37794 BC001487 BC059955 BC071657 AAH71657 BC095435 AAH95435 BI464234 BM716882 CD703666 CR533534 CAG38565 EF434181 ABO32290 EF434182 ABO32291 EF434183 ABO32292 EU446942 ABZ92471 HQ628633 AER93383 HQ628634 AER93384 HQ628635 AER93385 HQ628636 AER93386 HQ628637 AER93387 U23731 AAA70033 XR_946596 XR_946597 NM_007375 NP_031401
Function	DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. {ECO:0000269|PubMed:11285240, ECO:0000269|PubMed:17481916}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:17023659, ECO:0000269|PubMed:17481916}. Note=In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.
Tissue Specificity	Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TDP43 full length protein - ab156345 from Abcam Category Protein Source E. coli Species Human

Human TDP43 peptide - ab41970 from Abcam Category Peptide Species Human

Human TDP43 protein fragment - ab140718 from Abcam Category Protein Source E. coli Species Human

Human TDP43 protein fragment - ab40288 from Abcam Category Protein Source E. coli Species Human

Rat TDP43 peptide - ab45085 from Abcam Category Peptide Species Rat

TDP-43 / TARDBP Antibody Blocking Peptide - LS-E2685 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDP-43 / TARDBP Antibody Blocking Peptide - LS-E30371 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TDP-43 / TARDBP Antibody Blocking Peptide - LS-E30372 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

TDP-43 / TARDBP Antibody Blocking Peptide - LS-E12754 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDP-43 / TARDBP Antibody Blocking Peptide - LS-E12753 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDP-43 / TARDBP Antibody Blocking Peptide - LS-E26953 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TDP-43/TARDBP Blocking Peptide - NB110-55376PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

TDP-43/TARDBP Recombinant Protein - H00023435-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human TDP-43/TARDBP Protein - NBP2-22850 from Novus Biologicals Category Protein Prices $299.00, $373.00, $729.00, $884.00 Sizes 100 µg, 100 µg, 500 µg, 500 µg Species Human

Recombinant Human TDP-43/TARDBP Protein - NBP2-22849 from Novus Biologicals Category Protein Prices $299.00 Sizes 20 µg Species Human

TDP-43/TARDBP Blocking Peptide - NBP1-76814PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TDP-43/TARDBP Blocking Peptide - NBP1-76813PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

TARDBP-Antibody-N-term-Blocking-peptide - BP13763a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TDP43 blocking peptide - GTX88503-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Bovine

TARDBP Protein Lysate (APL00003) - APL00003 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

TARDBP Protein Lysate (APL10922) - APL10922 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

TARDBP Protein Lysate (APL10923) - APL10923 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

Human TARDBP (1-414) protein - orb191343 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli Species Human

Human TARDBP protein - orb244573 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human TARDBP protein - orb246155 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

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