| Gene Symbol |
PTP4A1
|
| Entrez Gene |
7803
|
| Alt Symbol |
HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein tyrosine phosphatase type IVA, member 1
|
| Other Description |
protein tyrosine phosphatase type IVA 1|protein tyrosine phosphatase type IVA protein 1|protein-tyrosine phosphatase 4a1|protein-tyrosine phosphatase of regenerating liver 1
|
| Swissprots |
Q49A54 B2R6C8 O00648 Q93096
|
| Accessions |
AAC39836 EAW88494 EAW88495 Q93096 AB451314 BAG70128 AB451444 BAG70258 AJ420505 AK312526 BAG35425 AW136267 BC023975 AAH23975 BC045571 AAH45571 BF436021 BG717869 BI222469 BP264358 BU632706 CA427371 CR749458 CAH18292 DQ890715 ABM81641 DQ893895 ABM84821 EU831599 ACE87199 EU831686 ACE86520 U48296 AAB40597 U69701 AAB09080 XM_011536111 XP_011534413 XM_011536112 XP_011534414 NM_003463 NP_003454
|
| Function |
Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. {ECO:0000269|PubMed:12235145, ECO:0000269|PubMed:12782572, ECO:0000269|PubMed:14643450}.
|
| Subcellular Location |
Cell membrane. Early endosome. Endoplasmic reticulum. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Note=And mitotic spindle.
|
| Tissue Specificity |
Expressed in bone marrow, lymph nodes, T lymphocytes, spleen, thymus and tonsil. Overexpressed in tumor cell lines. {ECO:0000269|PubMed:10940933, ECO:0000269|PubMed:12235145}.
|
