Gene Symbol | ADAM19 |
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Entrez Gene | 8728 |
Alt Symbol | FKSG34, MADDAM, MLTNB |
Species | Human |
Gene Type | protein-coding |
Description | ADAM metallopeptidase domain 19 |
Other Description | ADAM 19|a disintegrin and metalloproteinase domain 19 (meltrin beta)|disintegrin and metalloproteinase domain-containing protein 19|meltrin-beta|metalloprotease and disintegrin dendritic antigen marker|metalloprotease-disintegrin meltrin beta |
Swissprots | Q9UHP2 Q9BZL5 Q9H013 |
Accessions | EAW61595 EAW61596 EAW61597 EAW61598 Q9H013 AF134707 AAF22162 AF311317 AAK07852 AF326918 AAG50282 AK091464 BAG52367 AK093535 AK308182 AL049415 BC024214 AAH24214 BC033132 AAH33132 BC140323 AAI40324 HY088077 Y13786 CAC20585 XM_005266003 XP_005266060 XM_011534680 XP_011532982 XM_011534681 XP_011532983 XM_011534682 XP_011532984 NM_033274 NP_150377 NM_023038 |
Function | Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone (By similarity). {ECO:0000250}. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in many normal organ tissues and several cancer cell lines. |
ADAM19 CRISPR/Cas9 KO Plasmid (h) - sc-408791 from Santa Cruz Biotechnology
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ADAM19 HDR Plasmid (h) - sc-408791-HDR from Santa Cruz Biotechnology
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ADAM19 Double Nickase Plasmid (h) - sc-408791-NIC from Santa Cruz Biotechnology
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ADAM19 Double Nickase Plasmid (h2) - sc-408791-NIC-2 from Santa Cruz Biotechnology
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ADAM19 CRISPR Activation Plasmid (h) - sc-408791-ACT from Santa Cruz Biotechnology
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ADAM19 CRISPR Activation Plasmid (h2) - sc-408791-ACT-2 from Santa Cruz Biotechnology
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ADAM19 Lentiviral Activation Particles (h) - sc-408791-LAC from Santa Cruz Biotechnology
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ADAM19 Lentiviral Activation Particles (h2) - sc-408791-LAC-2 from Santa Cruz Biotechnology
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ADAM19 siRNA (h) - sc-41417 from Santa Cruz Biotechnology
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ADAM19 shRNA Plasmid (h) - sc-41417-SH from Santa Cruz Biotechnology
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ADAM19 shRNA (h) Lentiviral Particles - sc-41417-V from Santa Cruz Biotechnology
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ADAM19 RNAi - H00008728-R01 from Novus Biologicals
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MISSION® esiRNA - EHU046011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2808 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2808 from Sigma-Aldrich
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ADAM19 siRNA (Human) - CRH5748 from Cohesion Biosciences
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ADAM19 RNAi - H00008728-R02 from Novus Biologicals
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ADAM19 - MBS8239488 from MyBioSource
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shRNA set against Human ADAM1 (NM_033274.3) - SHH231378 from Creative biogene
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Human ADAM19 siRNA - orb266250 from Biorbyt
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ADAM19 shRNA Plasmid (Human) - CHH5748 from Cohesion Biosciences
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ADAM19 miRNA 3'UTR clone - MiUTR4H-TG00141 from Creative biogene
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