CDH1

Gene Symbol	CDH1
Entrez Gene	999
Alt Symbol	Arc-1, CD324, CDHE, ECAD, LCAM, UVO
Species	Human
Gene Type	protein-coding
Description	cadherin 1, type 1, E-cadherin (epithelial)
Other Description	CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin
Swissprots	Q14216 Q15855 Q9UII8 A8K1U7 P12830 Q4PJ14 Q16194 Q13799
Accessions	AAA21764 AAD14108 AAY68225 ADC53120 AKC34897 BAA08537 CAA84586 EAW83242 EAW83243 EAW83244 EAW83245 P12830 AB025105 BAA88956 AB025106 BAA88957 AI890107 AK290012 BAF82701 AK297913 BAG60232 AK309703 AK311198 AK312551 BAG35448 BC013851 BC141838 AAI41839 BC144283 BC146662 AAI46663 EU709494 ACD87624 L08599 AAA61259 X12790 CAA31279 X52279 CAA36522 Z13009 CAA78353 Z18923 CAA79356 XM_011523488 XP_011521790 XM_011523489 XP_011521791 NM_004360 NP_004351
Function	Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:16417575}.
Subcellular Location	Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane.
Tissue Specificity	Non-neural epithelial tissues.
Top Pathways	Rap1 signaling pathway, Adherens junction, Hippo signaling pathway, Bacterial invasion of epithelial cells, Thyroid cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Total E-Cadherin Sandwich ELISA Kit - 7886 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total E-Cadherin Sandwich ELISA Antibody Pair - 7887 from Cell Signaling Technology Category Antibody Pair

Human CDH1 / E Cadherin ELISA Kit (Sandwich ELISA) - LS-F2577 from LifeSpan Bioscience Category ELISA Kit Prices $610.00 Sizes 1 plate Sensitivity 15 pg/ml Range 4.113-1000 pg/ml

Mouse CDH1 / E Cadherin ELISA Kit (Sandwich ELISA) - LS-F2578 from LifeSpan Bioscience Category ELISA Kit Prices $610.00 Sizes 1 plate Sensitivity 156 pg/ml Range 4.113-1000 pg/ml

Human CDH1 / E Cadherin ELISA Kit (Sandwich ELISA) - LS-F3974 from LifeSpan Bioscience Category ELISA Kit Prices $470.00 Sizes 1 plate Sensitivity 0.069 ng/ml Range 4.113-1000 pg/ml

Mouse/Human/Rat CDH1 / E Cadherin ELISA Kit (Cell-Based ELISA) - LS-F1839 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 4.113-1000 pg/ml

Human CDH1 / E Cadherin ELISA Kit (Cell-Based ELISA) - LS-F1951 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 4.113-1000 pg/ml

Human CDH1 / E Cadherin ELISA Kit (Custom ELISA) - LS-F438 from LifeSpan Bioscience Category ELISA Kit Prices $670.00, $1,190.00, $2,570.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity To be determined Range 4.113-1000 pg/ml

Mouse CDH1 / E Cadherin ELISA Kit (Sandwich ELISA) - LS-F488 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 4.113 pg/ml Range 4.113-1000 pg/ml

Human CDH1 / E Cadherin ELISA Kit (Sandwich ELISA) - LS-F633 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 4.113-1000 pg/ml

Human CDH1 / E Cadherin ELISA Kit (Sandwich ELISA) - LS-F10980 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 4.113-1000 pg/ml

Human CDH1 / Cadherin-1 ELISA Kit - RAB0651 from Sigma-Aldrich Category ELISA Kit Prices $633.00 Sizes 1 kt

Mouse E-Cadherin ELISA Kit - RAB0088 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human E-Cadherin Quantikine ELISA Kit - DCADE0 from R&D Systems Category ELISA Kit Prices $509.00 Sizes 1 kit Sensitivity 0.09 ng/mL Range 0.3 - 20 ng/mL (Cell Culture Supernates, Serum, Heparin Plasma, Saliva, Urine)

Human E-Cadherin DuoSet ELISA - DY648 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 187.00 - 12,000 pg/mL

Mouse E-Cadherin DuoSet ELISA - DY748 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates)

Human Total E-Cadherin DuoSet IC Economy Pk, 15 Plate - DYC4225E from R&D Systems Category ELISA Kit

Human Total E-Cadherin DuoSet IC ELISA - DYC4225-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00, $1,395.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates), 1 pack (for 15 Plates) Range 156.00 - 10,000 pg/mL

Human Total E-Cadherin DuoSet IC, 5 Plate - DYC4225-5 from R&D Systems Category ELISA Kit

Quantikine Immunoassay Control Set 839 for Human E-Cadherin - QC78 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human E-Cadherin ELISA Kit - 55R-1706 from Fitzgerald Category ELISA Kit Prices $475.00 Sizes 1 kit

Mouse E Cadherin ELISA kit - 55R-2087 from Fitzgerald Category ELISA Kit Prices $505.00 Sizes 96 tests

Mouse E-Cadherin ELISA Kit - 55R-1707 from Fitzgerald Category ELISA Kit Prices $475.00 Sizes 1 kit

E-Cadherin ELISA Kit (Human) : 96 Wells (OKAG00117) - OKAG00117 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 188 pg/mL Range 188-12,000 pg/mL

CDH1 ELISA Pair Set - orb54924 from Biorbyt Category ELISA Kit Prices $646.00, $1,369.00 Sizes 5 plates, 15 plates

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