CDH1
| Gene Symbol | CDH1 |
|---|---|
| Entrez Gene | 999 |
| Alt Symbol | Arc-1, CD324, CDHE, ECAD, LCAM, UVO |
| Species | Human |
| Gene Type | protein-coding |
| Description | cadherin 1, type 1, E-cadherin (epithelial) |
| Other Description | CAM 120/80|E-Cadherin|cadherin 1, E-cadherin (epithelial)|cadherin-1|calcium-dependent adhesion protein, epithelial|cell-CAM 120/80|epithelial cadherin|uvomorulin |
| Swissprots | Q14216 Q15855 Q9UII8 A8K1U7 P12830 Q4PJ14 Q16194 Q13799 |
| Accessions | AAA21764 AAD14108 AAY68225 ADC53120 AKC34897 BAA08537 CAA84586 EAW83242 EAW83243 EAW83244 EAW83245 P12830 AB025105 BAA88956 AB025106 BAA88957 AI890107 AK290012 BAF82701 AK297913 BAG60232 AK309703 AK311198 AK312551 BAG35448 BC013851 BC141838 AAI41839 BC144283 BC146662 AAI46663 EU709494 ACD87624 L08599 AAA61259 X12790 CAA31279 X52279 CAA36522 Z13009 CAA78353 Z18923 CAA79356 XM_011523488 XP_011521790 XM_011523489 XP_011521791 NM_004360 NP_004351 |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7. {ECO:0000269|PubMed:16417575}. |
| Subcellular Location | Cell junction. Cell membrane; Single-pass type I membrane protein. Endosome. Golgi apparatus, trans-Golgi network. Note=Colocalizes with DLGAP5 at sites of cell-cell contact in intestinal epithelial cells. Anchored to actin microfilaments through association with alpha-, beta- and gamma- catenin. Sequential proteolysis induced by apoptosis or calcium influx, results in translocation from sites of cell-cell contact to the cytoplasm. Colocalizes with RAB11A endosomes during its transport from the Golgi apparatus to the plasma membrane. |
| Tissue Specificity | Non-neural epithelial tissues. |
| Top Pathways | Rap1 signaling pathway, Adherens junction, Hippo signaling pathway, Bacterial invasion of epithelial cells, Thyroid cancer |
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