| Gene Symbol | Notch3 |
|---|---|
| Entrez Gene | 18131 |
| Alt Symbol | AW229011, N3, hpbk |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | notch 3 |
| Other Description | Notch gene homolog 3|neurogenic locus notch homolog protein 3 |
| Swissprots | Q61982 |
| Accessions | EDL40331 Q61982 BC172738 AAI72738 X74760 CAA52776 NM_008716 NP_032742 |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development. {ECO:0000250}. |
| Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Proliferating neuroepithelium. |
| Top Pathways | Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation |