Gene Symbol | Notch3 |
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Entrez Gene | 18131 |
Alt Symbol | AW229011, N3, hpbk |
Species | Mouse |
Gene Type | protein-coding |
Description | notch 3 |
Other Description | Notch gene homolog 3|neurogenic locus notch homolog protein 3 |
Swissprots | Q61982 |
Accessions | EDL40331 Q61982 BC172738 AAI72738 X74760 CAA52776 NM_008716 NP_032742 |
Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). May play a role during CNS development. {ECO:0000250}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Proliferating neuroepithelium. |
Top Pathways | Notch signaling pathway, MicroRNAs in cancer, Dorso-ventral axis formation |
Notch 3 (Q-14) - sc-32347 from Santa Cruz Biotechnology
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Anti-NOTCH3 antibody [HMN3-133] (Phycoerythrin) - ab95775 from Abcam
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Notch-3 Antibody [Unconjugated] - AF1308 from Novus Biologicals
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Notch-3 Antibody [Biotin] - BAF1308 from Novus Biologicals
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Notch-3 Antibody (HMN3-133) [PE] - NBP2-00265 from Novus Biologicals
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Hamster ANTI NOTCH 3 Antibody (OASA11461) - OASA11461 from Aviva Systems Biology
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Hamster ANTI NOTCH 3 Antibody (OASA11462) - OASA11462 from Aviva Systems Biology
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NOTCH3 antibody [HMN3-133] - GTX39543 from GeneTex
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NOTCH3 antibody [HMN3-133] - GTX39544 from GeneTex
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Notch 3 antibody (PE) - 61R-1343 from Fitzgerald
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Notch Homolog 3 (Drosophila) Antibody - abx114156 from Abbexa
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NOTCH3 Antibody - abx032737 from Abbexa
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Alexa Fluor® 647 anti-mouse Notch 3 Antibody - 130511 from Biolegend
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PE anti-mouse Notch 3 Antibody - 130507 from Biolegend
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Purified anti-mouse Notch 3 Antibody - 130502 from Biolegend
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Notch3 Antibody [HMN3-133] (APC) - 77-001 from ProSci
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Notch3 Antibody [HMN3-133] (APC) - 77-002 from ProSci
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Mouse NOTCH 3 Antibody - GWB-Q00789 from Genway Biotech
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Mouse NOTCH 3 Antibody - GWB-Q00790 from Genway Biotech
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Anti-NOTCH3 monoclonal antibody, clone HMN3-133 - CABT-49819HM from Creative Diagnostics
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Notch3 Antibody (HMN3-133), PE conjugate, Molecular Probes™ - A18521 from Thermo Fisher Scientific
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Notch 3 Antibody | HMN3-133 - MCA5703GA from AbD Serotec
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Anti-Mouse Notch3 APC - 17-5763 from eBioscience
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Anti-Mouse Notch3 PE - 12-5763 from eBioscience
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NOTCH3 Antibody - CSB-PA015952GA01HU from Cusabio
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