| Gene Symbol | Hhip |
|---|---|
| Entrez Gene | 15245 |
| Alt Symbol | Hhip1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | Hedgehog-interacting protein |
| Other Description | hedgehog-interacting protein |
| Swissprots | Q8C0B0 Q9WU59 Q7TN16 |
| Accessions | CAK96037 EDL10879 Q7TN16 AF116865 AAD31172 AK031539 AK031841 BAC27575 AK034610 AK083190 AW121326 BC053012 AAH53012 BY142826 CV561558 XM_006530702 XP_006530765 NM_020259 NP_064655 |
| Function | Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:10050855}; Peripheral membrane protein {ECO:0000269|PubMed:10050855}. Secreted {ECO:0000269|PubMed:10050855}. Note=The last 22 C- terminal amino acids may participate in cell membrane attachment. |
| Tissue Specificity | In the adult brain, high expression found in the ventral cochlear nucleus, medial habenula, indusium griseum and tenia tecta. Some expression also in the caudate putamen, the nucleus accumbens, the ventral pallidum and in the superficial layers of the surerior colliculus. {ECO:0000269|PubMed:15019948}. |
| Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway |