Gene Symbol | Hhip |
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Entrez Gene | 15245 |
Alt Symbol | Hhip1 |
Species | Mouse |
Gene Type | protein-coding |
Description | Hedgehog-interacting protein |
Other Description | hedgehog-interacting protein |
Swissprots | Q8C0B0 Q9WU59 Q7TN16 |
Accessions | CAK96037 EDL10879 Q7TN16 AF116865 AAD31172 AK031539 AK031841 BAC27575 AK034610 AK083190 AW121326 BC053012 AAH53012 BY142826 CV561558 XM_006530702 XP_006530765 NM_020259 NP_064655 |
Function | Modulates hedgehog signaling in several cell types, including brain and lung through direct interaction with members of the hedgehog family. Soluble forms inhibit Shh-induced differentiation in the fibroblast cell line C3H/10T1/2. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:10050855}; Peripheral membrane protein {ECO:0000269|PubMed:10050855}. Secreted {ECO:0000269|PubMed:10050855}. Note=The last 22 C- terminal amino acids may participate in cell membrane attachment. |
Tissue Specificity | In the adult brain, high expression found in the ventral cochlear nucleus, medial habenula, indusium griseum and tenia tecta. Some expression also in the caudate putamen, the nucleus accumbens, the ventral pallidum and in the superficial layers of the surerior colliculus. {ECO:0000269|PubMed:15019948}. |
Top Pathways | Hedgehog signaling pathway, Basal cell carcinoma, cAMP signaling pathway |
Hhip CRISPR/Cas9 KO Plasmid (m) - sc-420853 from Santa Cruz Biotechnology
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Hhip HDR Plasmid (m) - sc-420853-HDR from Santa Cruz Biotechnology
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Hhip Double Nickase Plasmid (m) - sc-420853-NIC from Santa Cruz Biotechnology
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Hhip Double Nickase Plasmid (m2) - sc-420853-NIC-2 from Santa Cruz Biotechnology
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Hhip CRISPR Activation Plasmid (m) - sc-420853-ACT from Santa Cruz Biotechnology
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Hhip CRISPR Activation Plasmid (m2) - sc-420853-ACT-2 from Santa Cruz Biotechnology
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Hhip Lentiviral Activation Particles (m) - sc-420853-LAC from Santa Cruz Biotechnology
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Hhip Lentiviral Activation Particles (m2) - sc-420853-LAC-2 from Santa Cruz Biotechnology
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Hhip siRNA (m) - sc-40164 from Santa Cruz Biotechnology
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Hip shRNA Plasmid (m) - sc-40164-SH from Santa Cruz Biotechnology
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Hip shRNA (m) Lentiviral Particles - sc-40164-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU005481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33218 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33218 from Sigma-Aldrich
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HHIP siRNA (Mouse) - CRM1826 from Cohesion Biosciences
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HHIP - MBS8229037 from MyBioSource
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shRNA set against Mouse HHIP (NM_020259.4) - SHH311993 from Creative biogene
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Hhip CRISPR/Cas9 KO Plasmid (m2) - sc-420853-KO-2 from Santa Cruz Biotechnology
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Hhip HDR Plasmid (m2) - sc-420853-HDR-2 from Santa Cruz Biotechnology
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Mouse HHIP siRNA - orb281302 from Biorbyt
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HHIP shRNA Plasmid (Mouse) - CHM1826 from Cohesion Biosciences
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HHIP miRNA 3'UTR clone - MiUTR1M-05614 from Creative biogene
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