H2AFB1

Gene Symbol H2AFB1
Entrez Gene 474382
Alt Symbol H2A.Bbd
Species Human
Gene Type protein-coding
Description H2A histone family, member B1
Other Description H2A Barr body-deficient|histone H2A-Bbd type 1
Swissprots A0PK90 P0C5Y9
Accessions P0C5Y9 BC128034 AAI28035 CR542230 CAG47026 NM_001017990 NP_001017990
Function Atypical histone H2A which can replace conventional H2A in some nucleosomes and is associated with active transcription and mRNA processing. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. Nucleosomes containing this histone are less rigid and organize less DNA than canonical nucleosomes in vivo. They are enriched in actively transcribed genes and associate with the elongating form of RNA polymerase. They associate with spliceosome components and are required for mRNA splicing. May participate in spermatogenesis. {ECO:0000269|PubMed:15257289, ECO:0000269|PubMed:16287874, ECO:0000269|PubMed:16957777, ECO:0000269|PubMed:17591702, ECO:0000269|PubMed:17726088, ECO:0000269|PubMed:18329190, ECO:0000269|PubMed:22795134}.
Subcellular Location Nucleus. Chromosome. Note=Associated with the active X chromosome and with autosomes, while it is absent from the inactive X chromosome and excluded from Barr bodies.
Tissue Specificity Present in mature sperm. {ECO:0000269|PubMed:20008104}.
Top Pathways Systemic lupus erythematosus, Alcoholism

Histone H2A.Bbd CRISPR/Cas9 KO Plasmid (h) - sc-416845 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd HDR Plasmid (h) - sc-416845-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Double Nickase Plasmid (h) - sc-416845-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Double Nickase Plasmid (h2) - sc-416845-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd CRISPR Activation Plasmid (h) - sc-416845-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd CRISPR Activation Plasmid (h2) - sc-416845-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Lentiviral Activation Particles (h) - sc-416845-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.Bbd Lentiviral Activation Particles (h2) - sc-416845-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN9836 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9836 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00237 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00237

H2AFB1 siRNA (Human) - CRJ8350 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

H2AFB1 - MBS8234900 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human H2AFB1 (NM_001017990.1) - SHH309794 from Creative biogene

Category siRNA
Species Reactivities Human

H2AFB1 shRNA Plasmid (Human) - CHJ8350 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

H2AFB1 miRNA 3'UTR clone - MiUTR1H-04347 from Creative biogene

Species Reactivities Human
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