| Gene Symbol |
NEURL4
|
| Entrez Gene |
84461
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neuralized E3 ubiquitin protein ligase 4
|
| Other Description |
neuralized homolog 4|neuralized-like protein 4
|
| Swissprots |
Q9H0B0 Q96IU9 Q6GPI8 Q96JN8
|
| Accessions |
Q96JN8 AB058690 BAB47416 AL136870 CAB66804 AL833570 BC007227 AAH07227 BC073134 AAH73134 NM_001005408 NP_001005408 NM_032442 NP_115818
|
| Function |
Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}.
|
| Tissue Specificity |
Widely expressed at high levels (including brain). {ECO:0000269|PubMed:11347906}.
|
![Immunohistochemistry-Paraffin: NEURL4 Antibody [NBP2-33748] - Staining of human breast shows strong cytoplasmic positivity in myoepithelial cells.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_10/3866_NEURL4-Antibody-Immunohistochemistry-Paraffin-NBP2-33748-img0001.jpg)
![Immunocytochemistry/Immunofluorescence: NEURL4 Antibody [NBP1-93574] - Staining of human cell line U-2 OS shows positivity in nucleoli.](http://www.bioprodhub.com/system/product_images/ab_products/5/sub_9/9827_NEURL4-Antibody-Immunocytochemistry-Immunofluorescence-NBP1-93574-img0004.jpg)
