Gene Symbol | NEURL4 |
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Entrez Gene | 84461 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | neuralized E3 ubiquitin protein ligase 4 |
Other Description | neuralized homolog 4|neuralized-like protein 4 |
Swissprots | Q9H0B0 Q96IU9 Q6GPI8 Q96JN8 |
Accessions | Q96JN8 AB058690 BAB47416 AL136870 CAB66804 AL833570 BC007227 AAH07227 BC073134 AAH73134 NM_001005408 NP_001005408 NM_032442 NP_115818 |
Function | Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. |
Subcellular Location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. Note=Localizes to procentriole and daughter centriole in growing and quiescent cells (PubMed:22441691). May loose association with centrosomes during mitosis (PubMed:22261722). {ECO:0000269|PubMed:22261722, ECO:0000269|PubMed:22441691}. |
Tissue Specificity | Widely expressed at high levels (including brain). {ECO:0000269|PubMed:11347906}. |
NEURL4 CRISPR/Cas9 KO Plasmid (h) - sc-407452 from Santa Cruz Biotechnology
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NEURL4 HDR Plasmid (h) - sc-407452-HDR from Santa Cruz Biotechnology
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NEURL4 Double Nickase Plasmid (h) - sc-407452-NIC from Santa Cruz Biotechnology
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NEURL4 Double Nickase Plasmid (h2) - sc-407452-NIC-2 from Santa Cruz Biotechnology
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NEURL4 CRISPR Activation Plasmid (h) - sc-407452-ACT from Santa Cruz Biotechnology
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NEURL4 CRISPR Activation Plasmid (h2) - sc-407452-ACT-2 from Santa Cruz Biotechnology
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NEURL4 Lentiviral Activation Particles (h) - sc-407452-LAC from Santa Cruz Biotechnology
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NEURL4 Lentiviral Activation Particles (h2) - sc-407452-LAC-2 from Santa Cruz Biotechnology
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NEURL4 siRNA (h) - sc-93727 from Santa Cruz Biotechnology
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NEURL4 shRNA Plasmid (h) - sc-93727-SH from Santa Cruz Biotechnology
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NEURL4 shRNA (h) Lentiviral Particles - sc-93727-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU219801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15223 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15223 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04318 from Sigma-Aldrich
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NEURL4 siRNA (Human) - CRJ3489 from Cohesion Biosciences
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shRNA set against Human NEURL4 (NM_001005408.1) - SHH351544 from Creative biogene
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Human NEURL4 siRNA - orb273990 from Biorbyt
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NEURL4 shRNA Plasmid (Human) - CHJ3489 from Cohesion Biosciences
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NEURL4 miRNA 3'UTR clone - MiUTR1H-05287 from Creative biogene
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NEURL4 miRNA 3'UTR clone - MiUTR1H-05288 from Creative biogene
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