| Gene Symbol |
CXCL12
|
| Entrez Gene |
6387
|
| Alt Symbol |
IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X-C motif) ligand 12
|
| Other Description |
intercrine reduced in hepatomas|pre-B cell growth-stimulating factor|stromal cell-derived factor 1
|
| Swissprots |
H7BYN8 E7EVL0 Q6ICW0 P48061 Q2L985 Q5IT36 Q2L988 Q9H554 Q2L986 B2R4G0
|
| Accessions |
AAV49999 CAJ21099 CAJ21100 EAW86618 EAW86619 EAW86620 EAW86621 P48061 AI092156 AJ227905 AK090482 BAC03463 AK124641 AK292628 BAF85317 AK311814 BAG34757 AL713778 CAD28539 AU120056 AW014388 AY644456 AAT76437 AY874118 AAW82036 BC031072 BC039893 AAH39893 BX647204 CD172464 CR450283 CAG29279 DA266752 DQ345517 ABC69270 DQ345518 ABC69271 DQ345519 ABC69272 DQ345520 ABC69273 L36033 AAB39332 L36034 AAB39333 U16752 AAA97434 NM_000609 NP_000600 NM_001033886 NP_001029058 NM_001178134 NP_001171605 NM_001277990 NP_001264919 NM_199168 NP_954637
|
| Function |
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1- alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3- 67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-me
|
| Subcellular Location |
Secreted.
|
| Tissue Specificity |
Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen. {ECO:0000269|PubMed:16626895}.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Axon guidance, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Chemokine signaling pathway
|