Ddit3

Gene Symbol Ddit3
Entrez Gene 29467
Alt Symbol CHOP, CHOP-10, Chop10, Gadd153
Species Rat
Gene Type protein-coding
Description DNA-damage inducible transcript 3
Other Description C/EBP homologous protein|C/EBP zeta|CCAAT/enhancer-binding protein homologous protein|DDIT-3|DNA damage-inducible transcript 3 protein|c/EBP-homologous protein 10|growth arrest and DNA-damage-inducible protein GADD153
Swissprots Q62857
Accessions EDM16474 EDM16475 EDM16476 Q62857 AW916370 BC100664 AAI00665 BF282473 CF977695 U30186 AAA73629 U36994 AAA87944 XM_006241444 XP_006241506 XM_006241445 XP_006241507 NM_001109986 NP_001103456 NM_024134 NP_077048
Function Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the c
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. {ECO:0000250}.
Top Pathways MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer

DNA damage-inducible transcript 3 protein, Ddit3, Rat, ELISA Kit - E9115r from ARP American Research Products

Category ELISA Kit
Prices $660.00
Sizes 96 t
Range 0.625-40 ng/mL

Ddit3 - EKR1388 from Nordic BioSite

Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

Rat Ddit3 ELISA Kit - E081015 from Biobool

Category ELISA Kit

DDIT3 ELISA Kit (Rat) (OKEH03568) - OKEH03568 from Aviva Systems Biology

Category ELISA Kit
Prices $455.00
Sizes 96 wells
Sensitivity 0.3125 ng/mL
Range 0.625 - 40 ng/mL

Rat DNA damage-inducible transcript 3 protein ELISA Kit - EK4898 from Signalway Antibody

Category ELISA Kit
Prices $659.00
Sizes 1x96t
Sensitivity less than 0.078 ng/mL
Range 0.312-20 ng/mL

DNA damage-inducible transcript 3 protein, ELISA Kit - MBS760021 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.019ng/ml
Range 0.031-2ng/ml

DNA damage-inducible transcript 3 protein, ELISA Kit - MBS765004 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375ng/ml
Range 0.625-40ng/ml

DNA damage-inducible transcript 3 protein, ELISA Kit - MBS285053 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

DNA damage-inducible transcript 3 protein, ELISA Kit - MBS2882266 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 0.625-40 ng/mL

DNA damage-inducible transcript 3 protein, ELISA Kit - MBS9428724 from MyBioSource

Category ELISA Kit
Prices $605.00
Sizes 96 tests
Range 0.625-40 ng/mL
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