| Gene Symbol |
Ddit3
|
| Entrez Gene |
29467
|
| Alt Symbol |
CHOP, CHOP-10, Chop10, Gadd153
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
DNA-damage inducible transcript 3
|
| Other Description |
C/EBP homologous protein|C/EBP zeta|CCAAT/enhancer-binding protein homologous protein|DDIT-3|DNA damage-inducible transcript 3 protein|c/EBP-homologous protein 10|growth arrest and DNA-damage-inducible protein GADD153
|
| Swissprots |
Q62857
|
| Accessions |
EDM16474 EDM16475 EDM16476 Q62857 AW916370 BC100664 AAI00665 BF282473 CF977695 U30186 AAA73629 U36994 AAA87944 XM_006241444 XP_006241506 XM_006241445 XP_006241507 NM_001109986 NP_001103456 NM_024134 NP_077048
|
| Function |
Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the c
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. {ECO:0000250}.
|
| Top Pathways |
MAPK signaling pathway, Protein processing in endoplasmic reticulum, Non-alcoholic fatty liver disease (NAFLD), Transcriptional misregulation in cancer
|