| Gene Symbol |
ELMO3
|
| Entrez Gene |
79767
|
| Alt Symbol |
CED-12, CED12, ELMO-3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
engulfment and cell motility 3
|
| Other Description |
ced-12 homolog 3|engulfment and cell motility protein 3
|
| Swissprots |
Q9H8A5 B4DV86 Q96BJ8
|
| Accessions |
EAW83097 EAW83098 Q96BJ8 AI955864 AK023886 BAB14712 AK056923 AK300976 BAG62598 BC015524 AAH15524 BC034410 AAH34410 DA872517 DQ891332 ABM82258 DQ894515 ABM85441 XR_933432 NM_024712 NP_078988
|
| Function |
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Top Pathways |
Bacterial invasion of epithelial cells
|
