Gene Symbol | ELMO3 |
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Entrez Gene | 79767 |
Alt Symbol | CED-12, CED12, ELMO-3 |
Species | Human |
Gene Type | protein-coding |
Description | engulfment and cell motility 3 |
Other Description | ced-12 homolog 3|engulfment and cell motility protein 3 |
Swissprots | Q9H8A5 B4DV86 Q96BJ8 |
Accessions | EAW83097 EAW83098 Q96BJ8 AI955864 AK023886 BAB14712 AK056923 AK300976 BAG62598 BC015524 AAH15524 BC034410 AAH34410 DA872517 DQ891332 ABM82258 DQ894515 ABM85441 XR_933432 NM_024712 NP_078988 |
Function | Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in assocation with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1 (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. |
Top Pathways | Bacterial invasion of epithelial cells |
Elmo3 CRISPR/Cas9 KO Plasmid (h) - sc-413239 from Santa Cruz Biotechnology
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Elmo3 HDR Plasmid (h) - sc-413239-HDR from Santa Cruz Biotechnology
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Elmo3 Double Nickase Plasmid (h) - sc-413239-NIC from Santa Cruz Biotechnology
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Elmo3 Double Nickase Plasmid (h2) - sc-413239-NIC-2 from Santa Cruz Biotechnology
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Elmo3 CRISPR Activation Plasmid (h) - sc-413239-ACT from Santa Cruz Biotechnology
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Elmo3 CRISPR Activation Plasmid (h2) - sc-413239-ACT-2 from Santa Cruz Biotechnology
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Elmo3 Lentiviral Activation Particles (h) - sc-413239-LAC from Santa Cruz Biotechnology
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Elmo3 Lentiviral Activation Particles (h2) - sc-413239-LAC-2 from Santa Cruz Biotechnology
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Elmo3 siRNA (h) - sc-43750 from Santa Cruz Biotechnology
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Elmo3 shRNA Plasmid (h) - sc-43750-SH from Santa Cruz Biotechnology
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Elmo3 shRNA (h) Lentiviral Particles - sc-43750-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7814 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7814 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01460 from Sigma-Aldrich
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ELMO3 siRNA (Human) - CRJ2549 from Cohesion Biosciences
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ELMO3 - MBS8206857 from MyBioSource
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shRNA set against Human ELMO3 (NM_024712.3) - SHH285173 from Creative biogene
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shRNA set against Human ELMO3(NM_024712.3) - SHG210115 from Creative biogene
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Human ELMO3 siRNA - orb273050 from Biorbyt
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ELMO3 shRNA Plasmid (Human) - CHJ2549 from Cohesion Biosciences
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ELMO3 miRNA 3'UTR clone - MiUTR1H-03199 from Creative biogene
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