| Gene Symbol |
TDRD5
|
| Entrez Gene |
163589
|
| Alt Symbol |
TUDOR3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
tudor domain containing 5
|
| Other Description |
tudor domain-containing protein 5
|
| Swissprots |
A1L4G5 Q6ZSK2 B7ZLV0 Q8NAT2 Q5VTV0 Q5EBN4
|
| Accessions |
EAW91051 EAW91052 EAW91053 EAW91054 Q8NAT2 AK092142 BAC03815 AK126889 AK127370 BAC86946 BC043368 AAH43368 BC065707 BC089387 AAH89387 BC130532 AAI30533 BC144058 AAI44059 BG771449 DA418635 DB073297 XM_005244934 XP_005244991 XM_005244935 XP_005244992 NM_001199085 NP_001186014 NM_001199089 NP_001186018 NM_001199091 NP_001186020 NM_001199092 NP_001186021 NM_173533 NP_775804
|
| Function |
Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Note=Localizes to chromatoid body (CB) and pi-body (also called intermitochondrial cementin), 2 cytoplasmic ribonucleoprotein granules involved in RNA processing for spermatogenesis. {ECO:0000250}.
|
![Western Blot: TDRD5 Overexpression Lysate (Adult Normal) [NBP2-05110] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TDRD5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5940_TDRD5%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05110-img0001.jpg)