| Gene Symbol | FASN |
|---|---|
| Entrez Gene | 2194 |
| Alt Symbol | FAS, OA-519, SDR27X1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fatty acid synthase |
| Other Description | short chain dehydrogenase/reductase family 27X, member 1 |
| Swissprots | Q13479 Q969R1 P49327 Q4LE83 Q96C68 Q6P4U5 Q6SS02 Q16702 Q96IT0 |
| Accessions | AAC50536 EAW89745 P49327 AB209988 BAE06070 AY451392 AAS09886 BC007267 AAH07267 BC007305 BC007909 AAH07909 BC014631 AAH14631 BC014634 AAH14634 BC021544 BC063242 AAH63242 S80437 AAB35516 U26644 AAC50259 U29344 AAA73576 XM_011523538 XP_011521840 NM_004104 NP_004095 |
| Function | Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Ubiquitous. Prominent expression in brain, lung, and liver. {ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:7595075}. |
| Top Pathways | Insulin signaling pathway, AMPK signaling pathway, Fatty acid biosynthesis, Fatty acid metabolism |