| Gene Symbol |
FASN
|
| Entrez Gene |
2194
|
| Alt Symbol |
FAS, OA-519, SDR27X1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
fatty acid synthase
|
| Other Description |
short chain dehydrogenase/reductase family 27X, member 1
|
| Swissprots |
Q13479 Q969R1 P49327 Q4LE83 Q96C68 Q6P4U5 Q6SS02 Q16702 Q96IT0
|
| Accessions |
AAC50536 EAW89745 P49327 AB209988 BAE06070 AY451392 AAS09886 BC007267 AAH07267 BC007305 BC007909 AAH07909 BC014631 AAH14631 BC014634 AAH14634 BC021544 BC063242 AAH63242 S80437 AAB35516 U26644 AAC50259 U29344 AAA73576 XM_011523538 XP_011521840 NM_004104 NP_004095
|
| Function |
Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:17081065}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
|
| Tissue Specificity |
Ubiquitous. Prominent expression in brain, lung, and liver. {ECO:0000269|PubMed:7567999, ECO:0000269|PubMed:7595075}.
|
| Top Pathways |
Insulin signaling pathway, AMPK signaling pathway, Fatty acid biosynthesis, Fatty acid metabolism
|
![Western Blot: Fatty Acid Synthase Overexpression Lysate (Adult Normal) [NBP2-10566] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Fatty Acid Synthase.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2264_Fatty%2520Acid%2520Synthase%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10566-img0001.jpg)